Clinical Characteristics and Long-Term Outcomes of Movement Disorders in Childhood Thalamic Tumors

Zsila S. Sadighi, Jennifer Zabrowski, Frederick Boop, Alberto Broniscer, Amar Gajjar, Raja B. Khan

Research output: Contribution to journalArticle

Abstract

Background We studied the outcomes of movement disorders that were associated with childhood thalamic tumors. Methods We retrospectively reviewed 83 children with thalamic tumors treated at our institution from 1996 to 2013 to document the incidence and outcome of movement disorders. Magnetic resonance imaging was used to analyze the involvement of thalamic nuclei, and three instruments were used to rate the severity of the disorders. Results Nine (11%) patients had one or more of the following movement disorders: postural tremor, resting tremor, ballism, dystonia, myoclonus, and athetosis. Median age at tumor diagnosis was seven years (range, 0.25 to 11 years), and the average age at movement disorder onset was eight years (range, 1.5 to 11 years). Movement disorders developed at a median of 1.5 months (range, 0 to 4 months) after surgical resection. The severity of the disorders was either unchanged or slightly improved during follow-up. The red nuclei were the only thalamic structures that showed tumor involvement in all nine patients. Conclusions No specific injury of the thalamic nuclei was associated with movement disorders in children with thalamic tumors, and the severity of these disorders did not change over time.

Original languageEnglish (US)
Pages (from-to)71-77
Number of pages7
JournalPediatric Neurology
Volume65
DOIs
StatePublished - Dec 1 2016

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Movement Disorders
Thalamic Nuclei
Neoplasms
Tremor
Athetosis
Red Nucleus
Magnetic Resonance Imaging
Incidence
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Neurology
  • Developmental Neuroscience
  • Clinical Neurology

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Clinical Characteristics and Long-Term Outcomes of Movement Disorders in Childhood Thalamic Tumors. / Sadighi, Zsila S.; Zabrowski, Jennifer; Boop, Frederick; Broniscer, Alberto; Gajjar, Amar; Khan, Raja B.

In: Pediatric Neurology, Vol. 65, 01.12.2016, p. 71-77.

Research output: Contribution to journalArticle

Sadighi, Zsila S. ; Zabrowski, Jennifer ; Boop, Frederick ; Broniscer, Alberto ; Gajjar, Amar ; Khan, Raja B. / Clinical Characteristics and Long-Term Outcomes of Movement Disorders in Childhood Thalamic Tumors. In: Pediatric Neurology. 2016 ; Vol. 65. pp. 71-77.
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AU - Gajjar, Amar

AU - Khan, Raja B.

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