Clinical investigation of hospitalized human cases of West Nile virus infection in Houston, Texas, 2002-2004

Kristy O. Murray, S. Baraniuk, M. Resnick, R. Arafat, C. Kilborn, R. Shallenberger, T. L. York, D. Martinez, Marc Malkoff, N. Elgawley, W. McNeely, S. A. Khuwaja

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

The objective of this study was to describe the clinical features of cases hospitalized with West Nile virus (WNV) infections and identify clinical parameters that could potentially predict poor outcome (death). Retrospective medical chart reviews were completed for 172 confirmed cases of WNV infection hospitalized in the Houston, Texas, metropolitan area between 2002 and 2004. Of the 172 patients, 113 had encephalitis which resulted in 17 deaths, 47 had meningitis, and 12 had uncomplicated fever. Risk factors associated with progression from encephalitis to death were absence of pleocytosis in the cerebrospinal fluid, renal insufficiency, requiring intubation and mechanical ventilation, presence of myoclonus or tremors, and loss of consciousness. These findings can aid physicians in evaluating their patients suspected of WNV infection and determining outcomes in their patients with confirmed WNV neuroinvasive disease.

Original languageEnglish (US)
Pages (from-to)167-174
Number of pages8
JournalVector-Borne and Zoonotic Diseases
Volume8
Issue number2
DOIs
StatePublished - Apr 1 2008

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West Nile virus
Virus Diseases
Encephalitis
Myoclonus
Unconsciousness
Leukocytosis
Tremor
Meningitis
Artificial Respiration
Intubation
Renal Insufficiency
Cerebrospinal Fluid
Fever
Physicians

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Infectious Diseases
  • Virology

Cite this

Murray, K. O., Baraniuk, S., Resnick, M., Arafat, R., Kilborn, C., Shallenberger, R., ... Khuwaja, S. A. (2008). Clinical investigation of hospitalized human cases of West Nile virus infection in Houston, Texas, 2002-2004. Vector-Borne and Zoonotic Diseases, 8(2), 167-174. https://doi.org/10.1089/vbz.2007.0109

Clinical investigation of hospitalized human cases of West Nile virus infection in Houston, Texas, 2002-2004. / Murray, Kristy O.; Baraniuk, S.; Resnick, M.; Arafat, R.; Kilborn, C.; Shallenberger, R.; York, T. L.; Martinez, D.; Malkoff, Marc; Elgawley, N.; McNeely, W.; Khuwaja, S. A.

In: Vector-Borne and Zoonotic Diseases, Vol. 8, No. 2, 01.04.2008, p. 167-174.

Research output: Contribution to journalArticle

Murray, KO, Baraniuk, S, Resnick, M, Arafat, R, Kilborn, C, Shallenberger, R, York, TL, Martinez, D, Malkoff, M, Elgawley, N, McNeely, W & Khuwaja, SA 2008, 'Clinical investigation of hospitalized human cases of West Nile virus infection in Houston, Texas, 2002-2004', Vector-Borne and Zoonotic Diseases, vol. 8, no. 2, pp. 167-174. https://doi.org/10.1089/vbz.2007.0109
Murray, Kristy O. ; Baraniuk, S. ; Resnick, M. ; Arafat, R. ; Kilborn, C. ; Shallenberger, R. ; York, T. L. ; Martinez, D. ; Malkoff, Marc ; Elgawley, N. ; McNeely, W. ; Khuwaja, S. A. / Clinical investigation of hospitalized human cases of West Nile virus infection in Houston, Texas, 2002-2004. In: Vector-Borne and Zoonotic Diseases. 2008 ; Vol. 8, No. 2. pp. 167-174.
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