Clinical studies of a new latex particle agglutination test for detection of Haemophilus influenzae type b polyribose phosphate antigen in serum, cerebrospinal fluid and urine

E. D. Shaw, R. J. Darker, W. E. Feldman, B. M. Gray, Linda Pifer, G. B. Scott

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A new latex particle agglutination test for direct detection of Haemophilus influenzae type b polyribose phosphate antigen in serum, cerebrospinal fluid, or urine was evaluated from studies at four clinical centers. Although use of a serum buffer significantly reduced inconclusive agglutination of the latex particles, the retesting of serum samples, after heat inactivation and dilution, resolved all serum samples, with one exception, as reactive or nonreactive for the presence of the polyribose phosphate antigen. A clinical accuracy of 100% was obtained for the latex particle agglutination method in respect to its capability for detection of polyribose phosphate antigen in all patients with confirmed infection by H. influenzae type b.

Original languageEnglish (US)
Pages (from-to)1153-1156
Number of pages4
JournalJournal of Clinical Microbiology
Volume15
Issue number6
StatePublished - Aug 30 1982

Fingerprint

Latex Fixation Tests
Haemophilus influenzae type b
Microspheres
Cerebrospinal Fluid
Urine
Antigens
Agglutination
Serum
Buffers
Hot Temperature
Clinical Studies
polyribose phosphate
Infection

All Science Journal Classification (ASJC) codes

  • Microbiology (medical)

Cite this

Clinical studies of a new latex particle agglutination test for detection of Haemophilus influenzae type b polyribose phosphate antigen in serum, cerebrospinal fluid and urine. / Shaw, E. D.; Darker, R. J.; Feldman, W. E.; Gray, B. M.; Pifer, Linda; Scott, G. B.

In: Journal of Clinical Microbiology, Vol. 15, No. 6, 30.08.1982, p. 1153-1156.

Research output: Contribution to journalArticle

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