Clomipramine treatment in neonatal rats alters the brain acetylcholinesterase activity in adulthood

Vijayakumar Mavanji, Subimal Datta

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The enzyme, acetylcholinesterase, activity of the brain was measured in control and clomipramine-induced behaviorally depressed rats. Compared with control rats, the soluble form of acetylcholinesterase activity of the depressed rats was 31.8% higher in the hippocampus and 26.0% lower in the frontal cortex. However, the activity of soluble form of this enzyme was not significantly different in the hypothalamus, septum, and brainstem. These results suggest for the first time that the altered cholinergic activity in the specific areas of the brain may be involved in the behavioral depression observed in the rat model of human endogenous depression.

Original languageEnglish (US)
Article number22701
Pages (from-to)119-121
Number of pages3
JournalNeuroscience Letters
Volume330
Issue number1
DOIs
StatePublished - Jan 1 2002
Externally publishedYes

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Clomipramine
Acetylcholinesterase
Brain
Frontal Lobe
Enzymes
Depressive Disorder
Cholinergic Agents
Hypothalamus
Brain Stem
Hippocampus
Depression

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

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Clomipramine treatment in neonatal rats alters the brain acetylcholinesterase activity in adulthood. / Mavanji, Vijayakumar; Datta, Subimal.

In: Neuroscience Letters, Vol. 330, No. 1, 22701, 01.01.2002, p. 119-121.

Research output: Contribution to journalArticle

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