Cloning and characterization of a highly conserved HMG-like protein (Pf16) gene from plasmodium falciparum

Ramareddy Guntaka, Jagannadha C. Kandala, V. Dashwantha Reddy

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A novel gene encoding a protein of 147 amino acids (Pf16) has been cloned from Plasmodium falciparum and expressed in E. coli. The protein contains 19 methionines, all of which are localized in the NH2-terminal 35 amino acid residues, and it is also rich in lysine. Pf16 is highly basic, contains a polyacidic domain consisting of aspartic acid and is related to the non-histone high mobility group proteins of higher eukaryotes. The gene is conserved among eight different species of Plasmodium so far examined, suggesting an important function for this gene product in the parasite's life cycle.

Original languageEnglish (US)
Pages (from-to)412-419
Number of pages8
JournalBiochemical and Biophysical Research Communications
Volume182
Issue number1
DOIs
StatePublished - Jan 15 1992

Fingerprint

High Mobility Group Proteins
Cloning
Plasmodium falciparum
Organism Cloning
Genes
Amino Acids
Gene encoding
Aspartic Acid
Methionine
Escherichia coli
Lysine
Life cycle
Proteins
Plasmodium
Life Cycle Stages
Eukaryota
Parasites

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Cloning and characterization of a highly conserved HMG-like protein (Pf16) gene from plasmodium falciparum. / Guntaka, Ramareddy; Kandala, Jagannadha C.; Dashwantha Reddy, V.

In: Biochemical and Biophysical Research Communications, Vol. 182, No. 1, 15.01.1992, p. 412-419.

Research output: Contribution to journalArticle

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