Cloning of a novel Y-box homology protein (chkYB-1HP) cDNA lacking the cold-shock domain

Ashok Nambiar, Jagan C. Kandala, Jan Svoboda, Ramareddy Guntaka

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

We have isolated the complete cDNA clone of a novel 262 amino acid Chicken YB-1 Homology Protein (chkYB-1HP) by screening a chicken embryo cDNA expression library. While the chkYB-1HP is identical over its carboxyl- terminal 78 amino acids with the Y-box protein YB-1, it differs strikingly from all other Y-box transcription factors by lacking the cold-shock domain (CSD). We propose that proteins like chkYB-1HP that lack the CSD, but retain the hydrophilic carboxyl domain could regulate Y-box proteins through the formation of heterodimeric complexes.

Original languageEnglish (US)
Pages (from-to)1-6
Number of pages6
JournalBiochimica et Biophysica Acta - Gene Structure and Expression
Volume1395
Issue number1
DOIs
StatePublished - Jan 7 1998

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Cloning
Organism Cloning
Chickens
Shock
Complementary DNA
Y-Box-Binding Protein 1
Proteins
Cold Shock Proteins and Peptides
Amino Acids
Gene Library
Transcription Factors
Embryonic Structures
Clone Cells
Screening

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biophysics
  • Biochemistry
  • Genetics

Cite this

Cloning of a novel Y-box homology protein (chkYB-1HP) cDNA lacking the cold-shock domain. / Nambiar, Ashok; Kandala, Jagan C.; Svoboda, Jan; Guntaka, Ramareddy.

In: Biochimica et Biophysica Acta - Gene Structure and Expression, Vol. 1395, No. 1, 07.01.1998, p. 1-6.

Research output: Contribution to journalArticle

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