CNTF genotype is associated with muscular strength and quality in humans across the adult age span

Stephen M. Roth, Matthew A. Schrager, Robert E. Ferrell, Steven E. Riechman, E. Metter, Nicole A. Lynch, Rosemary S. Lindle, Ben F. Hurley

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

The relationship between ciliary neurotrophic factor (CNTF) genotype and muscle strength was examined in 494 healthy men and women across the entire adult age span (20-90 yr). Concentric (Con) and eccentric (Ecc) peak torque were assessed using a Kin-Com isokinetic dynamometer for the knee extensors (KE) and knee flexors (KF) at slow (0.52 rad/s) and faster (3.14 rad/s) velocities. The results were covaried for age, gender, and body mass or fat-free mass (FFM). Individuals heterozygous for the CNTF null (A allele) mutation (G/A) exhibited significantly higher Con peak torque of the KE and KF at 3.14 rad/s than G/G homozygotes when age, gender, and body mass were covaried (P < 0.05). When the dominant leg FFM (estimated muscle mass) was used in place of body mass as a covariate, Con peak torque of the KE at 3.14 rad/s was also significantly greater in the G/A individuals (P < 0.05). In addition, muscle quality of the KE (peak torque at 3.14 rad·s-1·leg muscle mass-1) was significantly greater in the G/A heterozygotes (P < 0.05). Similar results were seen in a subanalysis of subjects 60 yr and older, as well as in Caucasian subjects. In contrast, A/A homozygotes demonstrated significantly lower Ecc peak torque at 0.52 rad/s for both KE and KF compared with G/G and G/A groups (P < 0.05). No significant relationships were observed at 0.52 rad/s between genotype and Con peak torque. These data indicate that individuals exhibiting the G/A genotype possess significantly greater muscular strength and muscle quality at relatively fast contraction speeds than do G/G individuals. Because of high positive correlations between fast-velocity peak torque and muscular power, these findings suggest that further investigations should address the relationship between CNTF genotype and muscular power.

Original languageEnglish (US)
Pages (from-to)1205-1210
Number of pages6
JournalJournal of Applied Physiology
Volume90
Issue number4
StatePublished - 2001
Externally publishedYes

Fingerprint

Ciliary Neurotrophic Factor
Torque
Knee
Genotype
Homozygote
Muscle Strength
Muscles
Fats
Heterozygote
Leg
Alleles
Mutation

All Science Journal Classification (ASJC) codes

  • Physiology
  • Endocrinology
  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

Roth, S. M., Schrager, M. A., Ferrell, R. E., Riechman, S. E., Metter, E., Lynch, N. A., ... Hurley, B. F. (2001). CNTF genotype is associated with muscular strength and quality in humans across the adult age span. Journal of Applied Physiology, 90(4), 1205-1210.

CNTF genotype is associated with muscular strength and quality in humans across the adult age span. / Roth, Stephen M.; Schrager, Matthew A.; Ferrell, Robert E.; Riechman, Steven E.; Metter, E.; Lynch, Nicole A.; Lindle, Rosemary S.; Hurley, Ben F.

In: Journal of Applied Physiology, Vol. 90, No. 4, 2001, p. 1205-1210.

Research output: Contribution to journalArticle

Roth, SM, Schrager, MA, Ferrell, RE, Riechman, SE, Metter, E, Lynch, NA, Lindle, RS & Hurley, BF 2001, 'CNTF genotype is associated with muscular strength and quality in humans across the adult age span', Journal of Applied Physiology, vol. 90, no. 4, pp. 1205-1210.
Roth, Stephen M. ; Schrager, Matthew A. ; Ferrell, Robert E. ; Riechman, Steven E. ; Metter, E. ; Lynch, Nicole A. ; Lindle, Rosemary S. ; Hurley, Ben F. / CNTF genotype is associated with muscular strength and quality in humans across the adult age span. In: Journal of Applied Physiology. 2001 ; Vol. 90, No. 4. pp. 1205-1210.
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abstract = "The relationship between ciliary neurotrophic factor (CNTF) genotype and muscle strength was examined in 494 healthy men and women across the entire adult age span (20-90 yr). Concentric (Con) and eccentric (Ecc) peak torque were assessed using a Kin-Com isokinetic dynamometer for the knee extensors (KE) and knee flexors (KF) at slow (0.52 rad/s) and faster (3.14 rad/s) velocities. The results were covaried for age, gender, and body mass or fat-free mass (FFM). Individuals heterozygous for the CNTF null (A allele) mutation (G/A) exhibited significantly higher Con peak torque of the KE and KF at 3.14 rad/s than G/G homozygotes when age, gender, and body mass were covaried (P < 0.05). When the dominant leg FFM (estimated muscle mass) was used in place of body mass as a covariate, Con peak torque of the KE at 3.14 rad/s was also significantly greater in the G/A individuals (P < 0.05). In addition, muscle quality of the KE (peak torque at 3.14 rad·s-1·leg muscle mass-1) was significantly greater in the G/A heterozygotes (P < 0.05). Similar results were seen in a subanalysis of subjects 60 yr and older, as well as in Caucasian subjects. In contrast, A/A homozygotes demonstrated significantly lower Ecc peak torque at 0.52 rad/s for both KE and KF compared with G/G and G/A groups (P < 0.05). No significant relationships were observed at 0.52 rad/s between genotype and Con peak torque. These data indicate that individuals exhibiting the G/A genotype possess significantly greater muscular strength and muscle quality at relatively fast contraction speeds than do G/G individuals. Because of high positive correlations between fast-velocity peak torque and muscular power, these findings suggest that further investigations should address the relationship between CNTF genotype and muscular power.",
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