Cocaine-induced behavioral sensitization is associated with increased protein kinase C activin in the ventral tegmental area

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Abstract

The studies outlined below examined the effects of repeated cocaine-administration on protein kinase C activity within the mesocorticolimbic and nigrostriatal dopamine systems. Twenty-four hours after receiving daily injections of saline or cocaine animals were challenged with saline or 15 mg/kg cocaine and motor activity was measured for 2 hours. Protein kinase C activity was determined in brain samples collected immediately following acquisition of behavioral data. Animals receiving daily injections of 15.0 mg/kg cocaine demonstrated a behaviorally sensitized response to cocaine, which was associated with enhanced protein kinase C activity in the ventral tegmental area. These data suggest that increased protein kinase C activity in the ventral tegmental area may be important in the development of behavioral sensitization.

Original languageEnglish (US)
Pages (from-to)59-67
Number of pages9
JournalNeuroscience Research Communications
Volume20
Issue number1
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

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Activins
Ventral Tegmental Area
Cocaine
Protein Kinase C
Injections
Dopamine
Motor Activity
Brain

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

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title = "Cocaine-induced behavioral sensitization is associated with increased protein kinase C activin in the ventral tegmental area",
abstract = "The studies outlined below examined the effects of repeated cocaine-administration on protein kinase C activity within the mesocorticolimbic and nigrostriatal dopamine systems. Twenty-four hours after receiving daily injections of saline or cocaine animals were challenged with saline or 15 mg/kg cocaine and motor activity was measured for 2 hours. Protein kinase C activity was determined in brain samples collected immediately following acquisition of behavioral data. Animals receiving daily injections of 15.0 mg/kg cocaine demonstrated a behaviorally sensitized response to cocaine, which was associated with enhanced protein kinase C activity in the ventral tegmental area. These data suggest that increased protein kinase C activity in the ventral tegmental area may be important in the development of behavioral sensitization.",
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AB - The studies outlined below examined the effects of repeated cocaine-administration on protein kinase C activity within the mesocorticolimbic and nigrostriatal dopamine systems. Twenty-four hours after receiving daily injections of saline or cocaine animals were challenged with saline or 15 mg/kg cocaine and motor activity was measured for 2 hours. Protein kinase C activity was determined in brain samples collected immediately following acquisition of behavioral data. Animals receiving daily injections of 15.0 mg/kg cocaine demonstrated a behaviorally sensitized response to cocaine, which was associated with enhanced protein kinase C activity in the ventral tegmental area. These data suggest that increased protein kinase C activity in the ventral tegmental area may be important in the development of behavioral sensitization.

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