Cocaine-induced increases in medial prefrontal cortical GABA transmission involves glutamatergic receptors

Prathiba Jayaram, Jeffery Steketee

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

A recent study showed that cocaine-induced sensitization is associated with an increase in GABA (γ-aminobutyric acid) transmission in the medial prefrontal cortex. Since previous studies have demonstrated that sensitization is associated with enhanced medial prefrontal cortex glutamatergic transmission, the present study examined the role of N-methyl-d-aspartate (NMDA) and α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid/kainate (AMPA/KA) receptors in cocaine-induced increases in medial prefrontal cortex GABA levels. Male Sprague-Dawley rats received four daily injections of saline (1 ml/kg, i.p.) or cocaine (15 mg/kg). One day later, animals were infused with NMDA or AMPA/KA antagonists 3-[(R)-2 carboxypiperazin-4-yl]-propyl-1-phosphonic acid (CPP) and 6,7-dinitroquinoxaline-2,3-dione (DNQX), respectively, into medial prefrontal cortex via microdialysis probe for 60 min before receiving systemic challenge injections of saline or cocaine. Cocaine-sensitized animals showed an increase in extracellular medial prefrontal cortex GABA levels that was blocked by prior medial prefrontal cortex infusion of DNQX, but not CPP. These data indicate that enhanced medial prefrontal cortex GABA transmission seen in cocaine-sensitized animals involves glutamatergic stimulation of AMPA receptors.

Original languageEnglish (US)
Pages (from-to)74-79
Number of pages6
JournalEuropean Journal of Pharmacology
Volume531
Issue number1-3
DOIs
StatePublished - Feb 15 2006

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Prefrontal Cortex
Cocaine
gamma-Aminobutyric Acid
Aspartic Acid
Aminobutyrates
Kainic Acid Receptors
Injections
AMPA Receptors
Kainic Acid
Microdialysis
Sprague Dawley Rats
3-(2-carboxypiperazin-4-yl)propyl-1-phosphonic acid

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Cocaine-induced increases in medial prefrontal cortical GABA transmission involves glutamatergic receptors. / Jayaram, Prathiba; Steketee, Jeffery.

In: European Journal of Pharmacology, Vol. 531, No. 1-3, 15.02.2006, p. 74-79.

Research output: Contribution to journalArticle

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