Cognitive Decline in Older Persons Initiating Anticholinergic Medications

Raj C. Shah, Alicia L. Janos, Julia E. Kline, Lei Yu, Sue E. Leurgans, Robert S. Wilson, Peter Wei, David A. Bennett, Kenneth M. Heilman, Jack Tsao

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background:This study examines the effect of initiating medications with anticholinergic activity on the cognitive functions of older persons.Methods:Participants were 896 older community-dwelling, Catholic clergy without baseline dementia. Medication data was collected annually. The Anticholinergic Cognitive Burden Scale was utilized to identify use of a medication with probable or definite anticholinergic activity. Participants had at least two annual cognitive evaluations.Results:Over a mean follow-up of 10 years, the annual rate of global cognitive function decline for never users, prevalent users, and incident users was -0.062 (SE = 0.005), -0.081(SE = 0.011), and -0.096 (SE = 0.007) z-score units/year, respectively. Compared to never users, incident users had a more rapid decline (difference = -0.034 z-score units/year, SE = 0.008, p<0.001) while prevalent users did not have a significantly more rapid decline (p = 0.1).Conclusions:Older persons initiating a medication with anticholinergic activity have a steeper annual decline in cognitive functioning than those who are not taking these medications.

Original languageEnglish (US)
Article numbere64111
JournalPloS one
Volume8
Issue number5
DOIs
StatePublished - May 31 2013

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Cholinergic Antagonists
drug therapy
Cognition
cognition
Clergy
Independent Living
dementia
Dementia
Cognitive Dysfunction

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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Shah, R. C., Janos, A. L., Kline, J. E., Yu, L., Leurgans, S. E., Wilson, R. S., ... Tsao, J. (2013). Cognitive Decline in Older Persons Initiating Anticholinergic Medications. PloS one, 8(5), [e64111]. https://doi.org/10.1371/journal.pone.0064111

Cognitive Decline in Older Persons Initiating Anticholinergic Medications. / Shah, Raj C.; Janos, Alicia L.; Kline, Julia E.; Yu, Lei; Leurgans, Sue E.; Wilson, Robert S.; Wei, Peter; Bennett, David A.; Heilman, Kenneth M.; Tsao, Jack.

In: PloS one, Vol. 8, No. 5, e64111, 31.05.2013.

Research output: Contribution to journalArticle

Shah, RC, Janos, AL, Kline, JE, Yu, L, Leurgans, SE, Wilson, RS, Wei, P, Bennett, DA, Heilman, KM & Tsao, J 2013, 'Cognitive Decline in Older Persons Initiating Anticholinergic Medications', PloS one, vol. 8, no. 5, e64111. https://doi.org/10.1371/journal.pone.0064111
Shah RC, Janos AL, Kline JE, Yu L, Leurgans SE, Wilson RS et al. Cognitive Decline in Older Persons Initiating Anticholinergic Medications. PloS one. 2013 May 31;8(5). e64111. https://doi.org/10.1371/journal.pone.0064111
Shah, Raj C. ; Janos, Alicia L. ; Kline, Julia E. ; Yu, Lei ; Leurgans, Sue E. ; Wilson, Robert S. ; Wei, Peter ; Bennett, David A. ; Heilman, Kenneth M. ; Tsao, Jack. / Cognitive Decline in Older Persons Initiating Anticholinergic Medications. In: PloS one. 2013 ; Vol. 8, No. 5.
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