Cold-induced hypertension and diuresis

Zhongjie Sun, R. Cade

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Chronic exposure of rats to mild cold (5°C) resulted in a significant elevation of blood pressure (BP) within 4 days. Peripheral administration of losartan (AT1 receptor antagonist) could decrease the elevated BP to the control level. AT1 receptor mRNA was significantly increased in resistance arteries by exposure to cold. Chronic exposure to cold was accompanied by diuresis and a decrease in urine osmolality. The circulating level of arginine vasopressin (AVP) was not affected significantly by cold exposure. It is concluded that cold-induced hypertension may be maintained by up-regulation of AT1 receptors. Cold-induced diuresis may be due to decreased renal responsiveness to AVP rather than inhibition of AVP release.

Original languageEnglish (US)
Pages (from-to)105-109
Number of pages5
JournalJournal of Thermal Biology
Volume25
Issue number1-2
DOIs
StatePublished - Feb 1 2000

Fingerprint

diuresis
Arginine Vasopressin
Diuresis
hypertension
Blood pressure
Hypertension
arginine vasopressin
Losartan
Level control
chronic exposure
receptors
blood pressure
Rats
Blood Pressure
Messenger RNA
osmolality
Osmolar Concentration
arteries
antagonists
Up-Regulation

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)
  • Physiology

Cite this

Cold-induced hypertension and diuresis. / Sun, Zhongjie; Cade, R.

In: Journal of Thermal Biology, Vol. 25, No. 1-2, 01.02.2000, p. 105-109.

Research output: Contribution to journalArticle

Sun, Zhongjie ; Cade, R. / Cold-induced hypertension and diuresis. In: Journal of Thermal Biology. 2000 ; Vol. 25, No. 1-2. pp. 105-109.
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