Collaborative research in childhood cancer survivorship: The current landscape

Smita Bhatia, Saro H. Armenian, Gregory Armstrong, Eline Van Dulmen-Den Broeder, Michael M. Hawkins, Leontien C.M. Kremer, Claudia E. Kuehni, Jørgen H. Olsen, Leslie L. Robison, Melissa M. Hudson

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

Survivors of childhood cancer carry a substantial burden of morbidity and are at increased risk for premature death. Furthermore, clear associations exist between specific therapeutic exposures and the risk for a variety of long-term complications. The entire landscape of health issues encountered for decades after successful completion of treatment is currently being explored in various collaborative research settings. These settings include large population-based or multiinstitutional cohorts and single-institution studies. The ascertainment of outcomes has depended on self-reporting, linkage to registries, or clinical assessments. Survivorship research in the cooperative group setting, such as the Children's Oncology Group, has leveraged the clinical trials infrastructure to explore the molecular underpinnings of treatment-related adverse events, and to understand specific complications in the setting of randomized risk-reduction strategies. This review highlights the salient findings from these large collaborative initiatives, emphasizing the need for life-long follow-up of survivors of childhood cancer, and describing the development of several guidelines and efforts toward harmonization. Finally, the review reinforces the need to identify populations at highest risk, facilitating the development of risk prediction models that would allow for targeted interventions across the entire trajectory of survivorship.

Original languageEnglish (US)
Pages (from-to)3055-3064
Number of pages10
JournalJournal of Clinical Oncology
Volume33
Issue number27
DOIs
StatePublished - Sep 20 2015

Fingerprint

Survival Rate
Survivors
Research
Neoplasms
Premature Mortality
Risk Reduction Behavior
Registries
Therapeutics
Clinical Trials
Guidelines
Morbidity
Health
Population

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Bhatia, S., Armenian, S. H., Armstrong, G., Van Dulmen-Den Broeder, E., Hawkins, M. M., Kremer, L. C. M., ... Hudson, M. M. (2015). Collaborative research in childhood cancer survivorship: The current landscape. Journal of Clinical Oncology, 33(27), 3055-3064. https://doi.org/10.1200/JCO.2014.59.8052

Collaborative research in childhood cancer survivorship : The current landscape. / Bhatia, Smita; Armenian, Saro H.; Armstrong, Gregory; Van Dulmen-Den Broeder, Eline; Hawkins, Michael M.; Kremer, Leontien C.M.; Kuehni, Claudia E.; Olsen, Jørgen H.; Robison, Leslie L.; Hudson, Melissa M.

In: Journal of Clinical Oncology, Vol. 33, No. 27, 20.09.2015, p. 3055-3064.

Research output: Contribution to journalArticle

Bhatia, S, Armenian, SH, Armstrong, G, Van Dulmen-Den Broeder, E, Hawkins, MM, Kremer, LCM, Kuehni, CE, Olsen, JH, Robison, LL & Hudson, MM 2015, 'Collaborative research in childhood cancer survivorship: The current landscape', Journal of Clinical Oncology, vol. 33, no. 27, pp. 3055-3064. https://doi.org/10.1200/JCO.2014.59.8052
Bhatia S, Armenian SH, Armstrong G, Van Dulmen-Den Broeder E, Hawkins MM, Kremer LCM et al. Collaborative research in childhood cancer survivorship: The current landscape. Journal of Clinical Oncology. 2015 Sep 20;33(27):3055-3064. https://doi.org/10.1200/JCO.2014.59.8052
Bhatia, Smita ; Armenian, Saro H. ; Armstrong, Gregory ; Van Dulmen-Den Broeder, Eline ; Hawkins, Michael M. ; Kremer, Leontien C.M. ; Kuehni, Claudia E. ; Olsen, Jørgen H. ; Robison, Leslie L. ; Hudson, Melissa M. / Collaborative research in childhood cancer survivorship : The current landscape. In: Journal of Clinical Oncology. 2015 ; Vol. 33, No. 27. pp. 3055-3064.
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