Collagen in the hypertrophied, pressure-overloaded myocardium

Karl Weber, J. S. Janicki, R. Pick, C. Abrahams, S. G. Shroff, R. I. Bashey, R. M. Chen

Research output: Contribution to journalReview article

132 Citations (Scopus)

Abstract

The extracellular structural protein, collagen, is responsible for the functional integrity of the myocardium permitting reversible interdigitation and transmission of force beween contracting myocytes. In the pressure-overloaded, hypertrophied myocardium, clinical and experimental evidence indicates that the proportion of collagen relative to muscle is increased. Factors that appear to influence collagen growth during the hypertrophic process include age, species, the rapidity with which the overload occurs, the nature of the lesion leading to the pressure-overload, and the severity and duration of the overload. Morphologically, the heart's collagen matrix consists of a complex weave with tendinuous insertions that surrounds myocytes grouping them into myofibers, strands of collagen that connect adjoining myofibers, and collagenous struts that joint myocytes to other myocytes and capillaries. In a primate preparation of perinephritis with systemic hypertension, it was observed that the tendinous elements of the weave and the strands of collagen lying between myofibers were increased in number and physical dimension. The functional consequences of a remodeling of the collagen matrix that accompanied myocardial hypertrophy remain to eludicated. A better understanding of the dynamic behavior of the collagen matrix may offer new insights into the pathogenesis of ventricular dysfunction that accompanies the chronic pressure-overloaded state.

Original languageEnglish (US)
JournalCirculation
Volume75
Issue number1 II SUPPL. 1
StatePublished - Apr 2 1987

Fingerprint

Myocardium
Collagen
Pressure
Muscle Cells
Perinephritis
Ventricular Dysfunction
Hypertrophy
Primates
Joints
Hypertension
Muscles
Growth
Proteins

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Weber, K., Janicki, J. S., Pick, R., Abrahams, C., Shroff, S. G., Bashey, R. I., & Chen, R. M. (1987). Collagen in the hypertrophied, pressure-overloaded myocardium. Circulation, 75(1 II SUPPL. 1).

Collagen in the hypertrophied, pressure-overloaded myocardium. / Weber, Karl; Janicki, J. S.; Pick, R.; Abrahams, C.; Shroff, S. G.; Bashey, R. I.; Chen, R. M.

In: Circulation, Vol. 75, No. 1 II SUPPL. 1, 02.04.1987.

Research output: Contribution to journalReview article

Weber, K, Janicki, JS, Pick, R, Abrahams, C, Shroff, SG, Bashey, RI & Chen, RM 1987, 'Collagen in the hypertrophied, pressure-overloaded myocardium', Circulation, vol. 75, no. 1 II SUPPL. 1.
Weber K, Janicki JS, Pick R, Abrahams C, Shroff SG, Bashey RI et al. Collagen in the hypertrophied, pressure-overloaded myocardium. Circulation. 1987 Apr 2;75(1 II SUPPL. 1).
Weber, Karl ; Janicki, J. S. ; Pick, R. ; Abrahams, C. ; Shroff, S. G. ; Bashey, R. I. ; Chen, R. M. / Collagen in the hypertrophied, pressure-overloaded myocardium. In: Circulation. 1987 ; Vol. 75, No. 1 II SUPPL. 1.
@article{72c4ee5a0e0e4975af419ed40abe09aa,
title = "Collagen in the hypertrophied, pressure-overloaded myocardium",
abstract = "The extracellular structural protein, collagen, is responsible for the functional integrity of the myocardium permitting reversible interdigitation and transmission of force beween contracting myocytes. In the pressure-overloaded, hypertrophied myocardium, clinical and experimental evidence indicates that the proportion of collagen relative to muscle is increased. Factors that appear to influence collagen growth during the hypertrophic process include age, species, the rapidity with which the overload occurs, the nature of the lesion leading to the pressure-overload, and the severity and duration of the overload. Morphologically, the heart's collagen matrix consists of a complex weave with tendinuous insertions that surrounds myocytes grouping them into myofibers, strands of collagen that connect adjoining myofibers, and collagenous struts that joint myocytes to other myocytes and capillaries. In a primate preparation of perinephritis with systemic hypertension, it was observed that the tendinous elements of the weave and the strands of collagen lying between myofibers were increased in number and physical dimension. The functional consequences of a remodeling of the collagen matrix that accompanied myocardial hypertrophy remain to eludicated. A better understanding of the dynamic behavior of the collagen matrix may offer new insights into the pathogenesis of ventricular dysfunction that accompanies the chronic pressure-overloaded state.",
author = "Karl Weber and Janicki, {J. S.} and R. Pick and C. Abrahams and Shroff, {S. G.} and Bashey, {R. I.} and Chen, {R. M.}",
year = "1987",
month = "4",
day = "2",
language = "English (US)",
volume = "75",
journal = "Circulation",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "1 II SUPPL. 1",

}

TY - JOUR

T1 - Collagen in the hypertrophied, pressure-overloaded myocardium

AU - Weber, Karl

AU - Janicki, J. S.

AU - Pick, R.

AU - Abrahams, C.

AU - Shroff, S. G.

AU - Bashey, R. I.

AU - Chen, R. M.

PY - 1987/4/2

Y1 - 1987/4/2

N2 - The extracellular structural protein, collagen, is responsible for the functional integrity of the myocardium permitting reversible interdigitation and transmission of force beween contracting myocytes. In the pressure-overloaded, hypertrophied myocardium, clinical and experimental evidence indicates that the proportion of collagen relative to muscle is increased. Factors that appear to influence collagen growth during the hypertrophic process include age, species, the rapidity with which the overload occurs, the nature of the lesion leading to the pressure-overload, and the severity and duration of the overload. Morphologically, the heart's collagen matrix consists of a complex weave with tendinuous insertions that surrounds myocytes grouping them into myofibers, strands of collagen that connect adjoining myofibers, and collagenous struts that joint myocytes to other myocytes and capillaries. In a primate preparation of perinephritis with systemic hypertension, it was observed that the tendinous elements of the weave and the strands of collagen lying between myofibers were increased in number and physical dimension. The functional consequences of a remodeling of the collagen matrix that accompanied myocardial hypertrophy remain to eludicated. A better understanding of the dynamic behavior of the collagen matrix may offer new insights into the pathogenesis of ventricular dysfunction that accompanies the chronic pressure-overloaded state.

AB - The extracellular structural protein, collagen, is responsible for the functional integrity of the myocardium permitting reversible interdigitation and transmission of force beween contracting myocytes. In the pressure-overloaded, hypertrophied myocardium, clinical and experimental evidence indicates that the proportion of collagen relative to muscle is increased. Factors that appear to influence collagen growth during the hypertrophic process include age, species, the rapidity with which the overload occurs, the nature of the lesion leading to the pressure-overload, and the severity and duration of the overload. Morphologically, the heart's collagen matrix consists of a complex weave with tendinuous insertions that surrounds myocytes grouping them into myofibers, strands of collagen that connect adjoining myofibers, and collagenous struts that joint myocytes to other myocytes and capillaries. In a primate preparation of perinephritis with systemic hypertension, it was observed that the tendinous elements of the weave and the strands of collagen lying between myofibers were increased in number and physical dimension. The functional consequences of a remodeling of the collagen matrix that accompanied myocardial hypertrophy remain to eludicated. A better understanding of the dynamic behavior of the collagen matrix may offer new insights into the pathogenesis of ventricular dysfunction that accompanies the chronic pressure-overloaded state.

UR - http://www.scopus.com/inward/record.url?scp=0023150951&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0023150951&partnerID=8YFLogxK

M3 - Review article

VL - 75

JO - Circulation

JF - Circulation

SN - 0009-7322

IS - 1 II SUPPL. 1

ER -