Collagen molecules

Distribution of alpha chains

Julianne G. Nold, Andrew Kang, Jerome Gross

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

To ascertain the distribution of alpha chains within the collagen molecule, intramolecular cross-links were introduced into tropocollagen by reacting formaldehyde with dilute homogeneous molecular dispersions of collagen extracted from lathyritic guinea pig skin. Denaturation, chromatography on carboxymethyl cellulose, measurement of molecular weight, and analyses of the amino acids of the cross-linked product indicate that most, if not all, of the collagen molecules consist of two α1 chains and one α2 chain [(α1) 2(α2)1].

Original languageEnglish (US)
Pages (from-to)1096-1098
Number of pages3
JournalScience
Volume170
Issue number3962
DOIs
StatePublished - Jan 1 1970
Externally publishedYes

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Collagen
Tropocollagen
Carboxymethylcellulose Sodium
Formaldehyde
Chromatography
Guinea Pigs
Molecular Weight
Amino Acids
Skin

All Science Journal Classification (ASJC) codes

  • General

Cite this

Collagen molecules : Distribution of alpha chains. / Nold, Julianne G.; Kang, Andrew; Gross, Jerome.

In: Science, Vol. 170, No. 3962, 01.01.1970, p. 1096-1098.

Research output: Contribution to journalArticle

Nold, Julianne G. ; Kang, Andrew ; Gross, Jerome. / Collagen molecules : Distribution of alpha chains. In: Science. 1970 ; Vol. 170, No. 3962. pp. 1096-1098.
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