Collagen network remodelling and diastolic stiffness of the rat left ventricle with pressure overload hypertrophy

Christian W. Doering, Jorge E. Jalil, Joseph S. Janicki, Ruth Pick, Shahriar Aghili, Cyril Abrahams, Karl Weber

Research output: Contribution to journalReview article

224 Citations (Scopus)

Abstract

This study had two objectives: (a) to determine the accumulation of collagen and its structural remodelling in the hypertrophied rat left ventricle after 4 and 8 weeks of abdominal aorta banding; and (b) to correlate these findings with the diastolic stress-strain relation of the intact myocardium. In comparison to age and sex matched controls, the collagen volume fraction of the hypertrophied myocardium after 4 and 8 weeks of aortic banding increased significantly from 3.5(SD1.0)% to 7.8(4.2)% and 6.2(2.0)% respectively. This accumulation of collagen, or fibrosis, occurred in the absence of myocyte necrosis. Scanning electron microscopy showed increased density and thickness of the collagen weave and tendons. At 4 weeks, light microscopy showed interstitial oedema and disrupted collagen fibrils. Left ventricular diastolic stress-strain relations of both pressure overload groups were significantly steeper than that of the control group. Thus the response of the interstitium to the hypertrophic process that accompanies abdominal aorta banding is a complex process that includes a structural remodelling of the fibrillar collagen matrix and the early appearance of interstitial oedema, each of which may contribute to a rise in the passive stiffness of the intact myocardium.

Original languageEnglish (US)
Pages (from-to)686-695
Number of pages10
JournalCardiovascular research
Volume22
Issue number10
DOIs
StatePublished - Jan 1 1988

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Hypertrophy
Heart Ventricles
Collagen
Pressure
Myocardium
Abdominal Aorta
Edema
Fibrillar Collagens
Tendons
Electron Scanning Microscopy
Muscle Cells
Microscopy
Fibrosis
Necrosis
Light
Control Groups

All Science Journal Classification (ASJC) codes

  • Physiology
  • Cardiology and Cardiovascular Medicine
  • Physiology (medical)

Cite this

Collagen network remodelling and diastolic stiffness of the rat left ventricle with pressure overload hypertrophy. / Doering, Christian W.; Jalil, Jorge E.; Janicki, Joseph S.; Pick, Ruth; Aghili, Shahriar; Abrahams, Cyril; Weber, Karl.

In: Cardiovascular research, Vol. 22, No. 10, 01.01.1988, p. 686-695.

Research output: Contribution to journalReview article

Doering, Christian W. ; Jalil, Jorge E. ; Janicki, Joseph S. ; Pick, Ruth ; Aghili, Shahriar ; Abrahams, Cyril ; Weber, Karl. / Collagen network remodelling and diastolic stiffness of the rat left ventricle with pressure overload hypertrophy. In: Cardiovascular research. 1988 ; Vol. 22, No. 10. pp. 686-695.
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