Collagen‐induced arthritis in rats

John Stuart, Michael A. Cremer, Saryu N. Dixit, Andrew Kang, Alexander S. Townes

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

An oil emulsion of purified type I1 collagen from bovine articular cartilage when injected intradermally into rats induced an inflammatory polyarthritis in 4 of 12 animals. When similarly injected, collagen purified from bovine vitreous induced arthritis in 6 of 12 animals. Studies of humoral and cell‐mediated immunity to both collagen preparations demonstrated complete crossreactivity. It is concluded that vitreous collagen shares the arthritogenic property of cartilage‐derived type I1 collagen and that collagen from the two sources is indistinguishable in arthritogenic and immunologic properties. An oil emulsion of purified type II collagen from bovine articular cartilage when injected intradermally into rats induced an inflammatory polyarthritis in 4 of 12 animals. When similarly injected, collagen purified from bovine vitreous induced arthritis in 6 of 12 animals. Studies of humoral and cell‐mediated immunity to both collagen preparations demonstrated complete cross‐reactivity. It is concluded that vitreous collagen shares the arthritogenic property of cartilage‐derived type II collagen and that collagen from the two sources is indistinguishable in arthritogenic and immunologic properties.

Original languageEnglish (US)
Pages (from-to)347-352
Number of pages6
JournalArthritis & Rheumatism
Volume22
Issue number4
DOIs
StatePublished - Jan 1 1979

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Arthritis
Collagen
Collagen Type II
Articular Cartilage
Humoral Immunity
Emulsions
Oils

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Rheumatology
  • Immunology
  • Pharmacology (medical)

Cite this

Stuart, J., Cremer, M. A., Dixit, S. N., Kang, A., & Townes, A. S. (1979). Collagen‐induced arthritis in rats. Arthritis & Rheumatism, 22(4), 347-352. https://doi.org/10.1002/art.1780220406

Collagen‐induced arthritis in rats. / Stuart, John; Cremer, Michael A.; Dixit, Saryu N.; Kang, Andrew; Townes, Alexander S.

In: Arthritis & Rheumatism, Vol. 22, No. 4, 01.01.1979, p. 347-352.

Research output: Contribution to journalArticle

Stuart, J, Cremer, MA, Dixit, SN, Kang, A & Townes, AS 1979, 'Collagen‐induced arthritis in rats', Arthritis & Rheumatism, vol. 22, no. 4, pp. 347-352. https://doi.org/10.1002/art.1780220406
Stuart J, Cremer MA, Dixit SN, Kang A, Townes AS. Collagen‐induced arthritis in rats. Arthritis & Rheumatism. 1979 Jan 1;22(4):347-352. https://doi.org/10.1002/art.1780220406
Stuart, John ; Cremer, Michael A. ; Dixit, Saryu N. ; Kang, Andrew ; Townes, Alexander S. / Collagen‐induced arthritis in rats. In: Arthritis & Rheumatism. 1979 ; Vol. 22, No. 4. pp. 347-352.
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