Colposcopic acetowhitening of vulvar lesion

a validity study

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: To evaluate the acetowhite changes of the vulva as a predictor for high grade vulvar intraepithelial neoplasia. Methods: We performed retrospective analysis from 344 patients referred to our gynecology oncology clinic for genital dysplasia. All patients underwent vulvar colposcopy. Vulvar biopsies were performed for acetowhite changes and visible vulvar lesions such as ulceration, hyperpigmentation, and thickening of the vulvar tissue. High grade vulvar dysplasia was defined as vulvar intraepithelial neoplasia 2 or worse. Results of the vulvar pathology were collected and sensitivity, specificity, negative and positive predictive values. Results: Of the 344 women who underwent vulvoscopy 241 patients had acetowhite lesions, of whom 89 had true high grade dysplasia. Using colposcopic acetowhite changes as a marker for high grade vulvar dysplasia, the test’s sensitivity was 97 %, specificity was 40 %, negative predictive value was 98 %, and the positive predictive value was 37 %. Conclusion: Acetowhitening of the vulva has high sensitivity but low specificity as a predictor of high grade vulvar intraepithelial neoplasia. The absence of acetowhite lesion can reassure that high grade vulvar lesion is absent.

Original languageEnglish (US)
Pages (from-to)387-390
Number of pages4
JournalArchives of Gynecology and Obstetrics
Volume292
Issue number2
DOIs
StatePublished - Aug 10 2015

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Vulva
Sensitivity and Specificity
Neoplasms
Colposcopy
Hyperpigmentation
Gynecology
Pathology
Biopsy

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Colposcopic acetowhitening of vulvar lesion : a validity study. / Santoso, Joseph; Likes, Wendy.

In: Archives of Gynecology and Obstetrics, Vol. 292, No. 2, 10.08.2015, p. 387-390.

Research output: Contribution to journalArticle

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abstract = "Objective: To evaluate the acetowhite changes of the vulva as a predictor for high grade vulvar intraepithelial neoplasia. Methods: We performed retrospective analysis from 344 patients referred to our gynecology oncology clinic for genital dysplasia. All patients underwent vulvar colposcopy. Vulvar biopsies were performed for acetowhite changes and visible vulvar lesions such as ulceration, hyperpigmentation, and thickening of the vulvar tissue. High grade vulvar dysplasia was defined as vulvar intraepithelial neoplasia 2 or worse. Results of the vulvar pathology were collected and sensitivity, specificity, negative and positive predictive values. Results: Of the 344 women who underwent vulvoscopy 241 patients had acetowhite lesions, of whom 89 had true high grade dysplasia. Using colposcopic acetowhite changes as a marker for high grade vulvar dysplasia, the test’s sensitivity was 97 {\%}, specificity was 40 {\%}, negative predictive value was 98 {\%}, and the positive predictive value was 37 {\%}. Conclusion: Acetowhitening of the vulva has high sensitivity but low specificity as a predictor of high grade vulvar intraepithelial neoplasia. The absence of acetowhite lesion can reassure that high grade vulvar lesion is absent.",
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