Common carotid artery intima-media thickness and the risk of stroke recurrence

Georgios Tsivgoulis, Konstantinos Vemmos, Christos Papamichael, Konstantinos Spengos, Efstathios Manios, Kimon Stamatelopoulos, Demetrios Vassilopoulos, Nikolaos Zakopoulos

Research output: Contribution to journalArticle

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Abstract

BACKGROUND AND PURPOSE - Increased common carotid artery intima-media thickness (CCA-IMT) has been associated with an increased risk of myocardial infarction and stroke. We investigated the relationship between CCA-IMT and recurrent stroke in a cohort of ischemic stroke patients. METHODS - High-resolution B-mode ultrasonographic measurements of the CCA-IMT were performed in a consecutive series of 238 patients hospitalized in our institution with first-ever ischemic stroke. Stroke risk factors and secondary prevention therapies were documented. Patients were followed-up prospectively and the outcome event of interest was recurrent stroke. RESULTS - During a mean follow-up period of 28.9 months (range: 6 to 60 months), 27 recurrent strokes were documented. Patients who experienced recurrent cerebrovascular events had significantly (P=0.005) higher CCA-IMT values (1.01 mm, 95% CI:0.92 to 1.11 mm) than subjects who were free of stroke recurrence (0.88 mm, 95% CI:0.85 to 0.91 mm). After adjustment for baseline characteristics, risk factors and stroke subtypes and secondary prevention therapies increasing CCA-IMT was found to be an independent predictor of stroke recurrence. For each increment of 0.1 mm in CCA-IMT the probability of experiencing recurrent stroke increased by 18.0% (95% CI:2.0% to 36.0%, P=0.027). CONCLUSIONS - Increased CCA-IMT values are associated with a higher risk of long-term stroke recurrence.

Original languageEnglish (US)
Pages (from-to)1913-1916
Number of pages4
JournalStroke
Volume37
Issue number7
DOIs
StatePublished - Jul 1 2006

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Carotid Intima-Media Thickness
Common Carotid Artery
Stroke
Recurrence
Secondary Prevention
Myocardial Infarction

All Science Journal Classification (ASJC) codes

  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine
  • Advanced and Specialized Nursing

Cite this

Tsivgoulis, G., Vemmos, K., Papamichael, C., Spengos, K., Manios, E., Stamatelopoulos, K., ... Zakopoulos, N. (2006). Common carotid artery intima-media thickness and the risk of stroke recurrence. Stroke, 37(7), 1913-1916. https://doi.org/10.1161/01.STR.0000226399.13528.0a

Common carotid artery intima-media thickness and the risk of stroke recurrence. / Tsivgoulis, Georgios; Vemmos, Konstantinos; Papamichael, Christos; Spengos, Konstantinos; Manios, Efstathios; Stamatelopoulos, Kimon; Vassilopoulos, Demetrios; Zakopoulos, Nikolaos.

In: Stroke, Vol. 37, No. 7, 01.07.2006, p. 1913-1916.

Research output: Contribution to journalArticle

Tsivgoulis, G, Vemmos, K, Papamichael, C, Spengos, K, Manios, E, Stamatelopoulos, K, Vassilopoulos, D & Zakopoulos, N 2006, 'Common carotid artery intima-media thickness and the risk of stroke recurrence', Stroke, vol. 37, no. 7, pp. 1913-1916. https://doi.org/10.1161/01.STR.0000226399.13528.0a
Tsivgoulis G, Vemmos K, Papamichael C, Spengos K, Manios E, Stamatelopoulos K et al. Common carotid artery intima-media thickness and the risk of stroke recurrence. Stroke. 2006 Jul 1;37(7):1913-1916. https://doi.org/10.1161/01.STR.0000226399.13528.0a
Tsivgoulis, Georgios ; Vemmos, Konstantinos ; Papamichael, Christos ; Spengos, Konstantinos ; Manios, Efstathios ; Stamatelopoulos, Kimon ; Vassilopoulos, Demetrios ; Zakopoulos, Nikolaos. / Common carotid artery intima-media thickness and the risk of stroke recurrence. In: Stroke. 2006 ; Vol. 37, No. 7. pp. 1913-1916.
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AB - BACKGROUND AND PURPOSE - Increased common carotid artery intima-media thickness (CCA-IMT) has been associated with an increased risk of myocardial infarction and stroke. We investigated the relationship between CCA-IMT and recurrent stroke in a cohort of ischemic stroke patients. METHODS - High-resolution B-mode ultrasonographic measurements of the CCA-IMT were performed in a consecutive series of 238 patients hospitalized in our institution with first-ever ischemic stroke. Stroke risk factors and secondary prevention therapies were documented. Patients were followed-up prospectively and the outcome event of interest was recurrent stroke. RESULTS - During a mean follow-up period of 28.9 months (range: 6 to 60 months), 27 recurrent strokes were documented. Patients who experienced recurrent cerebrovascular events had significantly (P=0.005) higher CCA-IMT values (1.01 mm, 95% CI:0.92 to 1.11 mm) than subjects who were free of stroke recurrence (0.88 mm, 95% CI:0.85 to 0.91 mm). After adjustment for baseline characteristics, risk factors and stroke subtypes and secondary prevention therapies increasing CCA-IMT was found to be an independent predictor of stroke recurrence. For each increment of 0.1 mm in CCA-IMT the probability of experiencing recurrent stroke increased by 18.0% (95% CI:2.0% to 36.0%, P=0.027). CONCLUSIONS - Increased CCA-IMT values are associated with a higher risk of long-term stroke recurrence.

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