Common Variable Immune Deficiency and Associated Complications

Siddhi Gupta, Debendra Pattanaik, Guha Krishnaswamy

Research output: Contribution to journalReview article

Abstract

Common variable immunodeficiency disorders refer to a relatively common primary immune deficiency group of diseases that present with infectious and inflammatory complications secondary to defects in antibody production and sometimes in cellular immunity. The disorder often presents in middle age or later with recurrent sinopulmonary infections, bronchiectasis, or a plethora of noninfectious complications such as autoimmune disorders, granulomatous interstitial lung disease, GI diseases, malignancies (including lymphoma), and multisystem granulomatous disease resembling sarcoidosis. Infusion of immunoglobulin by IV or subcutaneous is the mainstay of therapy. Management of complications is often difficult as immune suppression may be necessary in these conditions and entails the use of medications and biologicals which may further increase the risk for infections. Specifically, bronchiectasis, granulomatous lymphocytic interstitial lung disease, repeated sinopulmonary infections, and malignancies are sequelae of antibody deficiency that may present to the pulmonologist. This review will provide an updated understanding of the molecular aspects, differential diagnosis, presentations, and the management of common variable immunodeficiency disorders.

Original languageEnglish (US)
Pages (from-to)579-593
Number of pages15
JournalChest
Volume156
Issue number3
DOIs
StatePublished - Sep 1 2019

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Common Variable Immunodeficiency
Agammaglobulinemia
Bronchiectasis
Intravenous Immunoglobulins
Splenomegaly
Sarcoidosis
Granuloma
Liver Diseases
Asthma
Interstitial Lung Diseases
Infection
Neoplasms
Cellular Immunity
Antibody Formation
Lymphoma
Differential Diagnosis
Antibodies
Lymphadenopathy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Pulmonary and Respiratory Medicine
  • Critical Care and Intensive Care Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Common Variable Immune Deficiency and Associated Complications. / Gupta, Siddhi; Pattanaik, Debendra; Krishnaswamy, Guha.

In: Chest, Vol. 156, No. 3, 01.09.2019, p. 579-593.

Research output: Contribution to journalReview article

Gupta, Siddhi ; Pattanaik, Debendra ; Krishnaswamy, Guha. / Common Variable Immune Deficiency and Associated Complications. In: Chest. 2019 ; Vol. 156, No. 3. pp. 579-593.
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