Common variants at 12q24 are associated with drinking behavior in Han Chinese1-3

Xueli Yang, Xiangfeng Lu, Laiyuan Wang, Shufeng Chen, Jianxin Li, Jie Cao, Jichun Chen, Yongchen Hao, Ying Li, Liancheng Zhao, Hongfan Li, Donghua Liu, Ligui Wang, Fanghong Lu, Chong Shen, Lin Yu, Xianping Wu, Qi Zhao, Xu Ji, Dongshuang Guo & 3 others Xiaozhong Peng, Jianfeng Huang, Dongfeng Gu

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Alcohol consumption is heritable, but genetic susceptibility to drinking behavior has not been investigated widely in genome-wide association studies. Objective: We aimed to identify susceptibility loci for drinking behavior (drinkers compared with nondrinkers) in Han Chinese. Design: We performed 2 genome-wide association studies including 1420 drinkers and 3590 nondrinkers in discovery, followed by a de novo replication analysis comprising 4896 drinkers and 13,293 nondrinkers. DNA samples of the subjects were collected for genotyping. Results: The association results of drinking behavior (drinkers or nondrinkers) showed a cluster of single nucleotide polymorphisms at 12q24 in discovery (P , 5 3 1028), with the strongest association for rs11066280 near C12orf51 (P-combined = 3.26 3 102215). Moreover, we observed the association with drinking behavior for a functional variant in ALDH2 at 12q24 (rs671, P-discovery = 5.17 3 10235). We also identified the association between rs11066280 and daily alcohol intake among drinkers (P-combined = 4.01 3 10221). Conclusion: Our data indicate that common variants at 12q24 may contribute to the susceptibility of drinking behavior in Han Chinese.

Original languageEnglish (US)
Pages (from-to)545-551
Number of pages7
JournalAmerican Journal of Clinical Nutrition
Volume97
Issue number3
DOIs
StatePublished - Mar 1 2013

Fingerprint

Drinking Behavior
Genome-Wide Association Study
Genetic Predisposition to Disease
Alcohol Drinking
Single Nucleotide Polymorphism
Alcohols
DNA

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Common variants at 12q24 are associated with drinking behavior in Han Chinese1-3. / Yang, Xueli; Lu, Xiangfeng; Wang, Laiyuan; Chen, Shufeng; Li, Jianxin; Cao, Jie; Chen, Jichun; Hao, Yongchen; Li, Ying; Zhao, Liancheng; Li, Hongfan; Liu, Donghua; Wang, Ligui; Lu, Fanghong; Shen, Chong; Yu, Lin; Wu, Xianping; Zhao, Qi; Ji, Xu; Guo, Dongshuang; Peng, Xiaozhong; Huang, Jianfeng; Gu, Dongfeng.

In: American Journal of Clinical Nutrition, Vol. 97, No. 3, 01.03.2013, p. 545-551.

Research output: Contribution to journalArticle

Yang, X, Lu, X, Wang, L, Chen, S, Li, J, Cao, J, Chen, J, Hao, Y, Li, Y, Zhao, L, Li, H, Liu, D, Wang, L, Lu, F, Shen, C, Yu, L, Wu, X, Zhao, Q, Ji, X, Guo, D, Peng, X, Huang, J & Gu, D 2013, 'Common variants at 12q24 are associated with drinking behavior in Han Chinese1-3', American Journal of Clinical Nutrition, vol. 97, no. 3, pp. 545-551. https://doi.org/10.3945/ajcn.112.046482
Yang, Xueli ; Lu, Xiangfeng ; Wang, Laiyuan ; Chen, Shufeng ; Li, Jianxin ; Cao, Jie ; Chen, Jichun ; Hao, Yongchen ; Li, Ying ; Zhao, Liancheng ; Li, Hongfan ; Liu, Donghua ; Wang, Ligui ; Lu, Fanghong ; Shen, Chong ; Yu, Lin ; Wu, Xianping ; Zhao, Qi ; Ji, Xu ; Guo, Dongshuang ; Peng, Xiaozhong ; Huang, Jianfeng ; Gu, Dongfeng. / Common variants at 12q24 are associated with drinking behavior in Han Chinese1-3. In: American Journal of Clinical Nutrition. 2013 ; Vol. 97, No. 3. pp. 545-551.
@article{9a01c46414f74221a4b98762858d6e99,
title = "Common variants at 12q24 are associated with drinking behavior in Han Chinese1-3",
abstract = "Background: Alcohol consumption is heritable, but genetic susceptibility to drinking behavior has not been investigated widely in genome-wide association studies. Objective: We aimed to identify susceptibility loci for drinking behavior (drinkers compared with nondrinkers) in Han Chinese. Design: We performed 2 genome-wide association studies including 1420 drinkers and 3590 nondrinkers in discovery, followed by a de novo replication analysis comprising 4896 drinkers and 13,293 nondrinkers. DNA samples of the subjects were collected for genotyping. Results: The association results of drinking behavior (drinkers or nondrinkers) showed a cluster of single nucleotide polymorphisms at 12q24 in discovery (P , 5 3 1028), with the strongest association for rs11066280 near C12orf51 (P-combined = 3.26 3 102215). Moreover, we observed the association with drinking behavior for a functional variant in ALDH2 at 12q24 (rs671, P-discovery = 5.17 3 10235). We also identified the association between rs11066280 and daily alcohol intake among drinkers (P-combined = 4.01 3 10221). Conclusion: Our data indicate that common variants at 12q24 may contribute to the susceptibility of drinking behavior in Han Chinese.",
author = "Xueli Yang and Xiangfeng Lu and Laiyuan Wang and Shufeng Chen and Jianxin Li and Jie Cao and Jichun Chen and Yongchen Hao and Ying Li and Liancheng Zhao and Hongfan Li and Donghua Liu and Ligui Wang and Fanghong Lu and Chong Shen and Lin Yu and Xianping Wu and Qi Zhao and Xu Ji and Dongshuang Guo and Xiaozhong Peng and Jianfeng Huang and Dongfeng Gu",
year = "2013",
month = "3",
day = "1",
doi = "10.3945/ajcn.112.046482",
language = "English (US)",
volume = "97",
pages = "545--551",
journal = "American Journal of Clinical Nutrition",
issn = "0002-9165",
publisher = "American Society for Nutrition",
number = "3",

}

TY - JOUR

T1 - Common variants at 12q24 are associated with drinking behavior in Han Chinese1-3

AU - Yang, Xueli

AU - Lu, Xiangfeng

AU - Wang, Laiyuan

AU - Chen, Shufeng

AU - Li, Jianxin

AU - Cao, Jie

AU - Chen, Jichun

AU - Hao, Yongchen

AU - Li, Ying

AU - Zhao, Liancheng

AU - Li, Hongfan

AU - Liu, Donghua

AU - Wang, Ligui

AU - Lu, Fanghong

AU - Shen, Chong

AU - Yu, Lin

AU - Wu, Xianping

AU - Zhao, Qi

AU - Ji, Xu

AU - Guo, Dongshuang

AU - Peng, Xiaozhong

AU - Huang, Jianfeng

AU - Gu, Dongfeng

PY - 2013/3/1

Y1 - 2013/3/1

N2 - Background: Alcohol consumption is heritable, but genetic susceptibility to drinking behavior has not been investigated widely in genome-wide association studies. Objective: We aimed to identify susceptibility loci for drinking behavior (drinkers compared with nondrinkers) in Han Chinese. Design: We performed 2 genome-wide association studies including 1420 drinkers and 3590 nondrinkers in discovery, followed by a de novo replication analysis comprising 4896 drinkers and 13,293 nondrinkers. DNA samples of the subjects were collected for genotyping. Results: The association results of drinking behavior (drinkers or nondrinkers) showed a cluster of single nucleotide polymorphisms at 12q24 in discovery (P , 5 3 1028), with the strongest association for rs11066280 near C12orf51 (P-combined = 3.26 3 102215). Moreover, we observed the association with drinking behavior for a functional variant in ALDH2 at 12q24 (rs671, P-discovery = 5.17 3 10235). We also identified the association between rs11066280 and daily alcohol intake among drinkers (P-combined = 4.01 3 10221). Conclusion: Our data indicate that common variants at 12q24 may contribute to the susceptibility of drinking behavior in Han Chinese.

AB - Background: Alcohol consumption is heritable, but genetic susceptibility to drinking behavior has not been investigated widely in genome-wide association studies. Objective: We aimed to identify susceptibility loci for drinking behavior (drinkers compared with nondrinkers) in Han Chinese. Design: We performed 2 genome-wide association studies including 1420 drinkers and 3590 nondrinkers in discovery, followed by a de novo replication analysis comprising 4896 drinkers and 13,293 nondrinkers. DNA samples of the subjects were collected for genotyping. Results: The association results of drinking behavior (drinkers or nondrinkers) showed a cluster of single nucleotide polymorphisms at 12q24 in discovery (P , 5 3 1028), with the strongest association for rs11066280 near C12orf51 (P-combined = 3.26 3 102215). Moreover, we observed the association with drinking behavior for a functional variant in ALDH2 at 12q24 (rs671, P-discovery = 5.17 3 10235). We also identified the association between rs11066280 and daily alcohol intake among drinkers (P-combined = 4.01 3 10221). Conclusion: Our data indicate that common variants at 12q24 may contribute to the susceptibility of drinking behavior in Han Chinese.

UR - http://www.scopus.com/inward/record.url?scp=84874308453&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84874308453&partnerID=8YFLogxK

U2 - 10.3945/ajcn.112.046482

DO - 10.3945/ajcn.112.046482

M3 - Article

VL - 97

SP - 545

EP - 551

JO - American Journal of Clinical Nutrition

JF - American Journal of Clinical Nutrition

SN - 0002-9165

IS - 3

ER -