Comparative responses to endothelin-2 and sarafotoxin 6b in the pulmonary vascular bed of the cat

R. K. Minkes, B. D. Nossaman, Peter Kvamme, P. J. Kadowitz

Research output: Contribution to journalArticle

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Abstract

Pulmonary vascular responses to endothelin-2 and sarafotoxin 6b were investigated in the feline pulmonary vascular bed under natural flow and constant flow conditions. Injections of endothelin-2 and sarafotoxin 6b in a dose of 0.3 nmol/kg iv increased pulmonary arterial and left atrial pressures and cardiac output, and caused a biphasic change in calculated pulmonary vascular resistance. Endothelin-2 caused a biphasic change in systemic arterial pressure, while sarafotoxin 6b only decreased arterial pressure. Under constant flow conditions in the intact-chest cat, injections of endothelin-2 and sarafotoxin 6b in doses of 0.1-1 nmol into the perfused lobar artery increased lobar arterial pressure in a dose-related manner but were less potent than the thromboxane A2 mimic, U46619. An ET analog with only the Cys1-Cys15 disulfide bond and an amidated carboxy terminus had no significant activity in the pulmonary vascular bed. The present data show that endothelin-2 and sarafotoxin 6b have significant vasoconstrictor activity in the pulmonary vascular bed of the cat.

Original languageEnglish (US)
Pages (from-to)211-214
Number of pages4
JournalCanadian Journal of Physiology and Pharmacology
Volume69
Issue number2
DOIs
StatePublished - Jan 1 1991
Externally publishedYes

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Endothelin-2
Blood Vessels
Cats
Lung
Arterial Pressure
15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid
Thromboxane A2
Injections
Atrial Pressure
Felidae
Vasoconstrictor Agents
Disulfides
Cardiac Output
Vascular Resistance
Thorax
Arteries

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pharmacology
  • Physiology (medical)

Cite this

Comparative responses to endothelin-2 and sarafotoxin 6b in the pulmonary vascular bed of the cat. / Minkes, R. K.; Nossaman, B. D.; Kvamme, Peter; Kadowitz, P. J.

In: Canadian Journal of Physiology and Pharmacology, Vol. 69, No. 2, 01.01.1991, p. 211-214.

Research output: Contribution to journalArticle

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