Comparative toxicology study of Cinnabar, Zhusha Anshenwan, methylmercury and mercuric chloride

Feng Kang, Kun Wu, Haiyang He, Qin Wu, Jie Liu, Yujian Kang, Jingzhen Shi

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To study the toxicity of Cinnabar and Cinnabar-containing traditional medicines (Zhusha Anshenwan) comparable to common mercurials. Method: The toxicity of methylmercury (MeHg), mercuric chloride (HgCl 2), Cinnabar and Zhusha Anshenwan was studied in cultured human liver HL-7702 cells and in mice following acute and subacute exposures. Result: The 50% lethal concentrations (LC50) of MeHg, HgCl2, Cinnabar and Zhusha Anshenwan in human liver HL-7702 cells were 4.4, 9.2, 2 460, 4 050 mg · L-1, respectively. Oral cinnabar at a dose of 20 g · kg-1 (clinical dosage 250 times) did not kill mouse, but no mouse could survive MeHg at a dose of 0.1 g · kg-1 or HgCl 2 at a dose of 0.15 g · kg-1. Subacute toxicity experiment indicated that HgCl2 retarded body weight gain with significant accumulation of Hg in the liver and kidney. In comparison, mercury accumulation after Cinnabar and Zhusha Anshenwan was insignificant. No apparent hepatic and renal dysfunctions were evident under the experimental conditions, but the metallothionein-2 mRNA levels were much higher in HgCl2 group than in other groups. Conclusion: Cinnabar and Zhusha Anshenwan are much less toxic than MeHg and HgCl2.

Original languageEnglish (US)
Pages (from-to)499-503
Number of pages5
JournalZhongguo Zhongyao Zazhi
Volume35
Issue number4
DOIs
StatePublished - Feb 1 2010
Externally publishedYes

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Mercuric Chloride
Toxicology
Liver
Kidney
Metallothionein
Poisons
Traditional Medicine
cinnabar
methylmercuric chloride
Mercury
Weight Gain
Body Weight
Messenger RNA

All Science Journal Classification (ASJC) codes

  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Complementary and alternative medicine
  • Pharmacology (medical)

Cite this

Comparative toxicology study of Cinnabar, Zhusha Anshenwan, methylmercury and mercuric chloride. / Kang, Feng; Wu, Kun; He, Haiyang; Wu, Qin; Liu, Jie; Kang, Yujian; Shi, Jingzhen.

In: Zhongguo Zhongyao Zazhi, Vol. 35, No. 4, 01.02.2010, p. 499-503.

Research output: Contribution to journalArticle

Kang, Feng ; Wu, Kun ; He, Haiyang ; Wu, Qin ; Liu, Jie ; Kang, Yujian ; Shi, Jingzhen. / Comparative toxicology study of Cinnabar, Zhusha Anshenwan, methylmercury and mercuric chloride. In: Zhongguo Zhongyao Zazhi. 2010 ; Vol. 35, No. 4. pp. 499-503.
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AB - Objective: To study the toxicity of Cinnabar and Cinnabar-containing traditional medicines (Zhusha Anshenwan) comparable to common mercurials. Method: The toxicity of methylmercury (MeHg), mercuric chloride (HgCl 2), Cinnabar and Zhusha Anshenwan was studied in cultured human liver HL-7702 cells and in mice following acute and subacute exposures. Result: The 50% lethal concentrations (LC50) of MeHg, HgCl2, Cinnabar and Zhusha Anshenwan in human liver HL-7702 cells were 4.4, 9.2, 2 460, 4 050 mg · L-1, respectively. Oral cinnabar at a dose of 20 g · kg-1 (clinical dosage 250 times) did not kill mouse, but no mouse could survive MeHg at a dose of 0.1 g · kg-1 or HgCl 2 at a dose of 0.15 g · kg-1. Subacute toxicity experiment indicated that HgCl2 retarded body weight gain with significant accumulation of Hg in the liver and kidney. In comparison, mercury accumulation after Cinnabar and Zhusha Anshenwan was insignificant. No apparent hepatic and renal dysfunctions were evident under the experimental conditions, but the metallothionein-2 mRNA levels were much higher in HgCl2 group than in other groups. Conclusion: Cinnabar and Zhusha Anshenwan are much less toxic than MeHg and HgCl2.

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