Comparison of antibiotic release from polymethylmethacrylate beads and sponge collagen

Paul L. Becker, Richard Smith, Robert S. Williams, Joseph P. Dutkowsky

Research output: Contribution to journalArticle

58 Citations (Scopus)

Abstract

The rates of elution of tobramycin in vitro were compared for polymethylmethacrylate beads impregnated with the powder form and an alternative biodegradable substance, sponge collagen. The impregnated polymethylmethacrylate beads initially had a lower zone of inhibition, but the rate of release was slow in comparison with that of the impregnated sponge collagen. The sponge collagen delivered a higher dose faster and with a shorter duration than the polymethylmethacrylate beads with the same antibiotic concentration in vitro, but the beads delivered a therapeutic concentration for longer periods. Because it deteriorates rapidly, sponge collagen may be unsatisfactory as an agent of antibiotic delivery in patients who have chronic osteomyelitis; however, it may be useful for patients who have acute trauma with highly contaminated bone or soft tissue, or during hemiarthroplasty revision, to deliver a high local concentration of antibiotic for a short period of time.

Original languageEnglish (US)
Pages (from-to)737-741
Number of pages5
JournalJournal of Orthopaedic Research
Volume12
Issue number5
DOIs
StatePublished - Jan 1 1994

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Porifera
Polymethyl Methacrylate
Collagen
Anti-Bacterial Agents
Hemiarthroplasty
Tobramycin
Osteomyelitis
Powders
Bone and Bones
Wounds and Injuries
In Vitro Techniques
Therapeutics

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine

Cite this

Comparison of antibiotic release from polymethylmethacrylate beads and sponge collagen. / Becker, Paul L.; Smith, Richard; Williams, Robert S.; Dutkowsky, Joseph P.

In: Journal of Orthopaedic Research, Vol. 12, No. 5, 01.01.1994, p. 737-741.

Research output: Contribution to journalArticle

Becker, Paul L. ; Smith, Richard ; Williams, Robert S. ; Dutkowsky, Joseph P. / Comparison of antibiotic release from polymethylmethacrylate beads and sponge collagen. In: Journal of Orthopaedic Research. 1994 ; Vol. 12, No. 5. pp. 737-741.
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