Comparison of Apolipoprotein (ApoB/ApoA-1) and Lipoprotein (Total Cholesterol/HDL) Ratios in Obese Adolescents

Ramin Alemzadeh, Jessica Kichler

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Serum (ApoB/ApoA-1) ratio is considered a stronger predictor of systemic inflammation and atherosclerosis than serum total cholesterol/HDL (TC/HDL) ratio among adults. We evaluated the relationships between ApoB/ApoA-1 and TC/HDL ratios with surrogate markers of inflammation and insulin resistance (IR) among obese adolescents. Methods: Body mass index z-score (BMI-z), body composition, fasting glucose, insulin, lipids, high-sensitive c-reactive protein (hs-CRP), hemoglobin A1c (HbA1c), and homeostatic model assessment for insulin resistance (HOMA-IR) were evaluated in 143 obese adolescents. Results: Male subjects had higher BMI-SDS, fat-free mass (FFM), and glucose than female subjects (P < 0.01). Furthermore, 54.5% met diagnostic criteria for metabolic syndrome (MS) and displayed higher SBP, BMI-SDS, fat mass (FM), HOMA-IR, hs-CRP, TG, TC/HDL, TG/HDL, ApoB/ApoA-1, and HbA1c, but lower HDL and ApoA-1 than the non-MS group (P < 0.05) with similar gender distribution. In the entire cohort, TC/HDL and ApoB/ApoA-1 ratios were strongly correlated (r = 0.81, P < 0.0001). Receiver operating characteristic analysis indicated that the area under the curve in MS subjects for ApoB/ApoA-1 and TC/HDL-C ratios was not statistically different. ApoB/ApoA-1 and TC/HDL-C ratios were positively correlated with SBP (r = 0.29; P = 0.0004) and (r = 0.43; P < 0.0001), respectively. Finally, ApoB/ApoA-1 and TC/HDL-C ratios were correlated with hs-CRP (r = 0.21; P = 0.014) and (r = 0.26; P = 0.0016), respectively. However, the relationships between ApoB/ApoA-1 and TC/HDL ratios with HOMA-IR were not statistically significant. Conclusions: Unlike in the adult population, serum ApoA-1, ApoB, and ApoB/ApoA-1 ratio may not have significant advantage over conventional lipoproteins in evaluating the presence of systemic inflammation, MS, and risk of atherosclerosis in obese adolescents.

Original languageEnglish (US)
Pages (from-to)40-45
Number of pages6
JournalMetabolic Syndrome and Related Disorders
Volume16
Issue number1
DOIs
StatePublished - Feb 1 2018

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Apolipoproteins
Apolipoprotein A-I
Apolipoproteins B
HDL Cholesterol
Insulin Resistance
Inflammation
Atherosclerosis
Hemoglobins
lipoprotein cholesterol
Serum
Fats
Glucose
Proteins
Body Composition
ROC Curve
Lipoproteins
Area Under Curve
Fasting
Body Mass Index
Biomarkers

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Comparison of Apolipoprotein (ApoB/ApoA-1) and Lipoprotein (Total Cholesterol/HDL) Ratios in Obese Adolescents. / Alemzadeh, Ramin; Kichler, Jessica.

In: Metabolic Syndrome and Related Disorders, Vol. 16, No. 1, 01.02.2018, p. 40-45.

Research output: Contribution to journalArticle

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abstract = "Background: Serum (ApoB/ApoA-1) ratio is considered a stronger predictor of systemic inflammation and atherosclerosis than serum total cholesterol/HDL (TC/HDL) ratio among adults. We evaluated the relationships between ApoB/ApoA-1 and TC/HDL ratios with surrogate markers of inflammation and insulin resistance (IR) among obese adolescents. Methods: Body mass index z-score (BMI-z), body composition, fasting glucose, insulin, lipids, high-sensitive c-reactive protein (hs-CRP), hemoglobin A1c (HbA1c), and homeostatic model assessment for insulin resistance (HOMA-IR) were evaluated in 143 obese adolescents. Results: Male subjects had higher BMI-SDS, fat-free mass (FFM), and glucose than female subjects (P < 0.01). Furthermore, 54.5{\%} met diagnostic criteria for metabolic syndrome (MS) and displayed higher SBP, BMI-SDS, fat mass (FM), HOMA-IR, hs-CRP, TG, TC/HDL, TG/HDL, ApoB/ApoA-1, and HbA1c, but lower HDL and ApoA-1 than the non-MS group (P < 0.05) with similar gender distribution. In the entire cohort, TC/HDL and ApoB/ApoA-1 ratios were strongly correlated (r = 0.81, P < 0.0001). Receiver operating characteristic analysis indicated that the area under the curve in MS subjects for ApoB/ApoA-1 and TC/HDL-C ratios was not statistically different. ApoB/ApoA-1 and TC/HDL-C ratios were positively correlated with SBP (r = 0.29; P = 0.0004) and (r = 0.43; P < 0.0001), respectively. Finally, ApoB/ApoA-1 and TC/HDL-C ratios were correlated with hs-CRP (r = 0.21; P = 0.014) and (r = 0.26; P = 0.0016), respectively. However, the relationships between ApoB/ApoA-1 and TC/HDL ratios with HOMA-IR were not statistically significant. Conclusions: Unlike in the adult population, serum ApoA-1, ApoB, and ApoB/ApoA-1 ratio may not have significant advantage over conventional lipoproteins in evaluating the presence of systemic inflammation, MS, and risk of atherosclerosis in obese adolescents.",
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AU - Kichler, Jessica

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N2 - Background: Serum (ApoB/ApoA-1) ratio is considered a stronger predictor of systemic inflammation and atherosclerosis than serum total cholesterol/HDL (TC/HDL) ratio among adults. We evaluated the relationships between ApoB/ApoA-1 and TC/HDL ratios with surrogate markers of inflammation and insulin resistance (IR) among obese adolescents. Methods: Body mass index z-score (BMI-z), body composition, fasting glucose, insulin, lipids, high-sensitive c-reactive protein (hs-CRP), hemoglobin A1c (HbA1c), and homeostatic model assessment for insulin resistance (HOMA-IR) were evaluated in 143 obese adolescents. Results: Male subjects had higher BMI-SDS, fat-free mass (FFM), and glucose than female subjects (P < 0.01). Furthermore, 54.5% met diagnostic criteria for metabolic syndrome (MS) and displayed higher SBP, BMI-SDS, fat mass (FM), HOMA-IR, hs-CRP, TG, TC/HDL, TG/HDL, ApoB/ApoA-1, and HbA1c, but lower HDL and ApoA-1 than the non-MS group (P < 0.05) with similar gender distribution. In the entire cohort, TC/HDL and ApoB/ApoA-1 ratios were strongly correlated (r = 0.81, P < 0.0001). Receiver operating characteristic analysis indicated that the area under the curve in MS subjects for ApoB/ApoA-1 and TC/HDL-C ratios was not statistically different. ApoB/ApoA-1 and TC/HDL-C ratios were positively correlated with SBP (r = 0.29; P = 0.0004) and (r = 0.43; P < 0.0001), respectively. Finally, ApoB/ApoA-1 and TC/HDL-C ratios were correlated with hs-CRP (r = 0.21; P = 0.014) and (r = 0.26; P = 0.0016), respectively. However, the relationships between ApoB/ApoA-1 and TC/HDL ratios with HOMA-IR were not statistically significant. Conclusions: Unlike in the adult population, serum ApoA-1, ApoB, and ApoB/ApoA-1 ratio may not have significant advantage over conventional lipoproteins in evaluating the presence of systemic inflammation, MS, and risk of atherosclerosis in obese adolescents.

AB - Background: Serum (ApoB/ApoA-1) ratio is considered a stronger predictor of systemic inflammation and atherosclerosis than serum total cholesterol/HDL (TC/HDL) ratio among adults. We evaluated the relationships between ApoB/ApoA-1 and TC/HDL ratios with surrogate markers of inflammation and insulin resistance (IR) among obese adolescents. Methods: Body mass index z-score (BMI-z), body composition, fasting glucose, insulin, lipids, high-sensitive c-reactive protein (hs-CRP), hemoglobin A1c (HbA1c), and homeostatic model assessment for insulin resistance (HOMA-IR) were evaluated in 143 obese adolescents. Results: Male subjects had higher BMI-SDS, fat-free mass (FFM), and glucose than female subjects (P < 0.01). Furthermore, 54.5% met diagnostic criteria for metabolic syndrome (MS) and displayed higher SBP, BMI-SDS, fat mass (FM), HOMA-IR, hs-CRP, TG, TC/HDL, TG/HDL, ApoB/ApoA-1, and HbA1c, but lower HDL and ApoA-1 than the non-MS group (P < 0.05) with similar gender distribution. In the entire cohort, TC/HDL and ApoB/ApoA-1 ratios were strongly correlated (r = 0.81, P < 0.0001). Receiver operating characteristic analysis indicated that the area under the curve in MS subjects for ApoB/ApoA-1 and TC/HDL-C ratios was not statistically different. ApoB/ApoA-1 and TC/HDL-C ratios were positively correlated with SBP (r = 0.29; P = 0.0004) and (r = 0.43; P < 0.0001), respectively. Finally, ApoB/ApoA-1 and TC/HDL-C ratios were correlated with hs-CRP (r = 0.21; P = 0.014) and (r = 0.26; P = 0.0016), respectively. However, the relationships between ApoB/ApoA-1 and TC/HDL ratios with HOMA-IR were not statistically significant. Conclusions: Unlike in the adult population, serum ApoA-1, ApoB, and ApoB/ApoA-1 ratio may not have significant advantage over conventional lipoproteins in evaluating the presence of systemic inflammation, MS, and risk of atherosclerosis in obese adolescents.

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