Comparison of atherosclerotic plaque burden and composition between diabetic and non diabetic patients by non invasive CT angiography

Uzoma N. Ibebuogu, Khurram Nasir, Ambarish Gopal, Naser Ahmadi, Song S. Mao, Emily Young, Lily Honoris, Vivek K. Nuguri, Robert S. Lee, Nudrat Usman, Babak Rostami, Raveen Pal, Ferdinand Flores, Matthew J. Budoff

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Type 2 diabetes mellitus (DM) is associated with a higher risk of cardiovascular disease and atherosclerotic burden. However little data exists in regards to plaque distribution and plaque composition in these patients. To assess for differences in the coronary plaques burden and composition among symptomatic patients with and without type 2 DM using multidetector computed tomography angiography (MDCTA). The 416 symptomatic patients (64% males, mean age: 61 ± 13 years) with 61 (15%) reporting type 2 DM, who underwent contrast-enhanced MDCTA were studied. Enrolled patients had an intermediate to high pre-test probability of obstructive coronary artery disease. Multivariate analysis was used to correct for differences in age and gender. Patients with type 2 DM were more likely to have significant stenosis ≥70% in at least one coronary segments (33% in type 2 DM vs. 18% in non diabetic, P = 0.013), whereas 11% of both type 2 DM and non diabetics had stenosis of 50-70% (P = NS). Also type 2 DM patients had a higher number of coronary segments with mixed plaques compared to nondiabetic patients (1.67 ± 2.01 vs. 1.23 ± 1.61, P = 0.05), whereas no such differences were observed for non-calcified or calcified plaques. Nearly half (43%) of type 2 DM had coronary artery calcium scores (CACS) ≥400 vs. 29% in non diabetic patients (P = 0.03). Patients with type 2 DM tend to have atherosclerotic plaques which are more likely to be mixed in nature. Future studies need to elucidate the prognostic value of differences in plaque characteristics observed according to type 2 diabetic status.

Original languageEnglish (US)
Pages (from-to)717-723
Number of pages7
JournalInternational Journal of Cardiovascular Imaging
Volume25
Issue number7
DOIs
StatePublished - Jul 27 2009

Fingerprint

Atherosclerotic Plaques
Type 2 Diabetes Mellitus
Multidetector Computed Tomography
Pathologic Constriction
Computed Tomography Angiography
Coronary Artery Disease
Coronary Vessels
Cardiovascular Diseases
Multivariate Analysis
Calcium

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging
  • Cardiology and Cardiovascular Medicine

Cite this

Comparison of atherosclerotic plaque burden and composition between diabetic and non diabetic patients by non invasive CT angiography. / Ibebuogu, Uzoma N.; Nasir, Khurram; Gopal, Ambarish; Ahmadi, Naser; Mao, Song S.; Young, Emily; Honoris, Lily; Nuguri, Vivek K.; Lee, Robert S.; Usman, Nudrat; Rostami, Babak; Pal, Raveen; Flores, Ferdinand; Budoff, Matthew J.

In: International Journal of Cardiovascular Imaging, Vol. 25, No. 7, 27.07.2009, p. 717-723.

Research output: Contribution to journalArticle

Ibebuogu, UN, Nasir, K, Gopal, A, Ahmadi, N, Mao, SS, Young, E, Honoris, L, Nuguri, VK, Lee, RS, Usman, N, Rostami, B, Pal, R, Flores, F & Budoff, MJ 2009, 'Comparison of atherosclerotic plaque burden and composition between diabetic and non diabetic patients by non invasive CT angiography', International Journal of Cardiovascular Imaging, vol. 25, no. 7, pp. 717-723. https://doi.org/10.1007/s10554-009-9483-9
Ibebuogu, Uzoma N. ; Nasir, Khurram ; Gopal, Ambarish ; Ahmadi, Naser ; Mao, Song S. ; Young, Emily ; Honoris, Lily ; Nuguri, Vivek K. ; Lee, Robert S. ; Usman, Nudrat ; Rostami, Babak ; Pal, Raveen ; Flores, Ferdinand ; Budoff, Matthew J. / Comparison of atherosclerotic plaque burden and composition between diabetic and non diabetic patients by non invasive CT angiography. In: International Journal of Cardiovascular Imaging. 2009 ; Vol. 25, No. 7. pp. 717-723.
@article{3f92f2cd298549e29396ad4fbde1c4e0,
title = "Comparison of atherosclerotic plaque burden and composition between diabetic and non diabetic patients by non invasive CT angiography",
abstract = "Type 2 diabetes mellitus (DM) is associated with a higher risk of cardiovascular disease and atherosclerotic burden. However little data exists in regards to plaque distribution and plaque composition in these patients. To assess for differences in the coronary plaques burden and composition among symptomatic patients with and without type 2 DM using multidetector computed tomography angiography (MDCTA). The 416 symptomatic patients (64{\%} males, mean age: 61 ± 13 years) with 61 (15{\%}) reporting type 2 DM, who underwent contrast-enhanced MDCTA were studied. Enrolled patients had an intermediate to high pre-test probability of obstructive coronary artery disease. Multivariate analysis was used to correct for differences in age and gender. Patients with type 2 DM were more likely to have significant stenosis ≥70{\%} in at least one coronary segments (33{\%} in type 2 DM vs. 18{\%} in non diabetic, P = 0.013), whereas 11{\%} of both type 2 DM and non diabetics had stenosis of 50-70{\%} (P = NS). Also type 2 DM patients had a higher number of coronary segments with mixed plaques compared to nondiabetic patients (1.67 ± 2.01 vs. 1.23 ± 1.61, P = 0.05), whereas no such differences were observed for non-calcified or calcified plaques. Nearly half (43{\%}) of type 2 DM had coronary artery calcium scores (CACS) ≥400 vs. 29{\%} in non diabetic patients (P = 0.03). Patients with type 2 DM tend to have atherosclerotic plaques which are more likely to be mixed in nature. Future studies need to elucidate the prognostic value of differences in plaque characteristics observed according to type 2 diabetic status.",
author = "Ibebuogu, {Uzoma N.} and Khurram Nasir and Ambarish Gopal and Naser Ahmadi and Mao, {Song S.} and Emily Young and Lily Honoris and Nuguri, {Vivek K.} and Lee, {Robert S.} and Nudrat Usman and Babak Rostami and Raveen Pal and Ferdinand Flores and Budoff, {Matthew J.}",
year = "2009",
month = "7",
day = "27",
doi = "10.1007/s10554-009-9483-9",
language = "English (US)",
volume = "25",
pages = "717--723",
journal = "International Journal of Cardiovascular Imaging",
issn = "1569-5794",
publisher = "Springer Netherlands",
number = "7",

}

TY - JOUR

T1 - Comparison of atherosclerotic plaque burden and composition between diabetic and non diabetic patients by non invasive CT angiography

AU - Ibebuogu, Uzoma N.

AU - Nasir, Khurram

AU - Gopal, Ambarish

AU - Ahmadi, Naser

AU - Mao, Song S.

AU - Young, Emily

AU - Honoris, Lily

AU - Nuguri, Vivek K.

AU - Lee, Robert S.

AU - Usman, Nudrat

AU - Rostami, Babak

AU - Pal, Raveen

AU - Flores, Ferdinand

AU - Budoff, Matthew J.

PY - 2009/7/27

Y1 - 2009/7/27

N2 - Type 2 diabetes mellitus (DM) is associated with a higher risk of cardiovascular disease and atherosclerotic burden. However little data exists in regards to plaque distribution and plaque composition in these patients. To assess for differences in the coronary plaques burden and composition among symptomatic patients with and without type 2 DM using multidetector computed tomography angiography (MDCTA). The 416 symptomatic patients (64% males, mean age: 61 ± 13 years) with 61 (15%) reporting type 2 DM, who underwent contrast-enhanced MDCTA were studied. Enrolled patients had an intermediate to high pre-test probability of obstructive coronary artery disease. Multivariate analysis was used to correct for differences in age and gender. Patients with type 2 DM were more likely to have significant stenosis ≥70% in at least one coronary segments (33% in type 2 DM vs. 18% in non diabetic, P = 0.013), whereas 11% of both type 2 DM and non diabetics had stenosis of 50-70% (P = NS). Also type 2 DM patients had a higher number of coronary segments with mixed plaques compared to nondiabetic patients (1.67 ± 2.01 vs. 1.23 ± 1.61, P = 0.05), whereas no such differences were observed for non-calcified or calcified plaques. Nearly half (43%) of type 2 DM had coronary artery calcium scores (CACS) ≥400 vs. 29% in non diabetic patients (P = 0.03). Patients with type 2 DM tend to have atherosclerotic plaques which are more likely to be mixed in nature. Future studies need to elucidate the prognostic value of differences in plaque characteristics observed according to type 2 diabetic status.

AB - Type 2 diabetes mellitus (DM) is associated with a higher risk of cardiovascular disease and atherosclerotic burden. However little data exists in regards to plaque distribution and plaque composition in these patients. To assess for differences in the coronary plaques burden and composition among symptomatic patients with and without type 2 DM using multidetector computed tomography angiography (MDCTA). The 416 symptomatic patients (64% males, mean age: 61 ± 13 years) with 61 (15%) reporting type 2 DM, who underwent contrast-enhanced MDCTA were studied. Enrolled patients had an intermediate to high pre-test probability of obstructive coronary artery disease. Multivariate analysis was used to correct for differences in age and gender. Patients with type 2 DM were more likely to have significant stenosis ≥70% in at least one coronary segments (33% in type 2 DM vs. 18% in non diabetic, P = 0.013), whereas 11% of both type 2 DM and non diabetics had stenosis of 50-70% (P = NS). Also type 2 DM patients had a higher number of coronary segments with mixed plaques compared to nondiabetic patients (1.67 ± 2.01 vs. 1.23 ± 1.61, P = 0.05), whereas no such differences were observed for non-calcified or calcified plaques. Nearly half (43%) of type 2 DM had coronary artery calcium scores (CACS) ≥400 vs. 29% in non diabetic patients (P = 0.03). Patients with type 2 DM tend to have atherosclerotic plaques which are more likely to be mixed in nature. Future studies need to elucidate the prognostic value of differences in plaque characteristics observed according to type 2 diabetic status.

UR - http://www.scopus.com/inward/record.url?scp=69249212229&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=69249212229&partnerID=8YFLogxK

U2 - 10.1007/s10554-009-9483-9

DO - 10.1007/s10554-009-9483-9

M3 - Article

C2 - 19633998

AN - SCOPUS:69249212229

VL - 25

SP - 717

EP - 723

JO - International Journal of Cardiovascular Imaging

JF - International Journal of Cardiovascular Imaging

SN - 1569-5794

IS - 7

ER -