Comparison of clinical and genetic variables of cardiac events associated with loud noise versus swimming among subjects with the long QT syndrome

Arthur J. Moss, Jennifer L. Robinson, Laura Gessman, Robert Gillespie, Wojciech Zareba, Peter J. Schwartz, G. Michael Vincent, Jesaia Benhorin, Emanuela Locati Heilbron, Jeffrey Towbin, Silvia G. Priori, Carlo Napolitano, Li Zhang, Aharon Medina, Mark L. Andrews, Katherine Timothy

Research output: Contribution to journalArticle

173 Citations (Scopus)

Abstract

Acute auditory stimuli and swimming activities are frequently associated with syncope, aborted cardiac arrest, and death in the long QT syndrome (LQTS). We investigated the clinical and genetic findings associated with cardiac events precipitated by these arousal factors. The study population involved 195 patients with an index cardiac event associated with a loud noise (n = 77) or swimming activity (n = 118). Patients with events associated with loud auditory stimuli were older at their index event and were more likely to be women than patients who experienced events during swimming-related activities. Patients with an index event associated with loud noise were likely to have subsequent events related to auditory stimuli; patients with an index event associated with swimming were likely to have recurrent events related to swimming or physical activities. Family patterning of auditory and swimming and/or physical activity-related events was evident. Genotype analyses in 25 patients revealed a significant difference in the distribution of index cardiac events by genotype (p <0.001), with all 19 patients with swimming-related episodes associated with LQT1 genotype and 5 of 6 patients with auditory-related events associated with LQT2 genotype. The clinical profile and genotype findings of patients with LQTS who experience cardiac events related to acute auditory stimuli are quite different from those who experience events accompanying swimming activities.

Original languageEnglish (US)
Pages (from-to)876-879
Number of pages4
JournalAmerican Journal of Cardiology
Volume84
Issue number8
DOIs
StatePublished - Oct 15 1999
Externally publishedYes

Fingerprint

Long QT Syndrome
Noise
Genotype
Exercise
Syncope
Arousal
Heart Arrest

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Comparison of clinical and genetic variables of cardiac events associated with loud noise versus swimming among subjects with the long QT syndrome. / Moss, Arthur J.; Robinson, Jennifer L.; Gessman, Laura; Gillespie, Robert; Zareba, Wojciech; Schwartz, Peter J.; Vincent, G. Michael; Benhorin, Jesaia; Heilbron, Emanuela Locati; Towbin, Jeffrey; Priori, Silvia G.; Napolitano, Carlo; Zhang, Li; Medina, Aharon; Andrews, Mark L.; Timothy, Katherine.

In: American Journal of Cardiology, Vol. 84, No. 8, 15.10.1999, p. 876-879.

Research output: Contribution to journalArticle

Moss, AJ, Robinson, JL, Gessman, L, Gillespie, R, Zareba, W, Schwartz, PJ, Vincent, GM, Benhorin, J, Heilbron, EL, Towbin, J, Priori, SG, Napolitano, C, Zhang, L, Medina, A, Andrews, ML & Timothy, K 1999, 'Comparison of clinical and genetic variables of cardiac events associated with loud noise versus swimming among subjects with the long QT syndrome', American Journal of Cardiology, vol. 84, no. 8, pp. 876-879. https://doi.org/10.1016/S0002-9149(99)00458-0
Moss, Arthur J. ; Robinson, Jennifer L. ; Gessman, Laura ; Gillespie, Robert ; Zareba, Wojciech ; Schwartz, Peter J. ; Vincent, G. Michael ; Benhorin, Jesaia ; Heilbron, Emanuela Locati ; Towbin, Jeffrey ; Priori, Silvia G. ; Napolitano, Carlo ; Zhang, Li ; Medina, Aharon ; Andrews, Mark L. ; Timothy, Katherine. / Comparison of clinical and genetic variables of cardiac events associated with loud noise versus swimming among subjects with the long QT syndrome. In: American Journal of Cardiology. 1999 ; Vol. 84, No. 8. pp. 876-879.
@article{97f392545961496282ac091ada4aa83a,
title = "Comparison of clinical and genetic variables of cardiac events associated with loud noise versus swimming among subjects with the long QT syndrome",
abstract = "Acute auditory stimuli and swimming activities are frequently associated with syncope, aborted cardiac arrest, and death in the long QT syndrome (LQTS). We investigated the clinical and genetic findings associated with cardiac events precipitated by these arousal factors. The study population involved 195 patients with an index cardiac event associated with a loud noise (n = 77) or swimming activity (n = 118). Patients with events associated with loud auditory stimuli were older at their index event and were more likely to be women than patients who experienced events during swimming-related activities. Patients with an index event associated with loud noise were likely to have subsequent events related to auditory stimuli; patients with an index event associated with swimming were likely to have recurrent events related to swimming or physical activities. Family patterning of auditory and swimming and/or physical activity-related events was evident. Genotype analyses in 25 patients revealed a significant difference in the distribution of index cardiac events by genotype (p <0.001), with all 19 patients with swimming-related episodes associated with LQT1 genotype and 5 of 6 patients with auditory-related events associated with LQT2 genotype. The clinical profile and genotype findings of patients with LQTS who experience cardiac events related to acute auditory stimuli are quite different from those who experience events accompanying swimming activities.",
author = "Moss, {Arthur J.} and Robinson, {Jennifer L.} and Laura Gessman and Robert Gillespie and Wojciech Zareba and Schwartz, {Peter J.} and Vincent, {G. Michael} and Jesaia Benhorin and Heilbron, {Emanuela Locati} and Jeffrey Towbin and Priori, {Silvia G.} and Carlo Napolitano and Li Zhang and Aharon Medina and Andrews, {Mark L.} and Katherine Timothy",
year = "1999",
month = "10",
day = "15",
doi = "10.1016/S0002-9149(99)00458-0",
language = "English (US)",
volume = "84",
pages = "876--879",
journal = "American Journal of Cardiology",
issn = "0002-9149",
publisher = "Elsevier Inc.",
number = "8",

}

TY - JOUR

T1 - Comparison of clinical and genetic variables of cardiac events associated with loud noise versus swimming among subjects with the long QT syndrome

AU - Moss, Arthur J.

AU - Robinson, Jennifer L.

AU - Gessman, Laura

AU - Gillespie, Robert

AU - Zareba, Wojciech

AU - Schwartz, Peter J.

AU - Vincent, G. Michael

AU - Benhorin, Jesaia

AU - Heilbron, Emanuela Locati

AU - Towbin, Jeffrey

AU - Priori, Silvia G.

AU - Napolitano, Carlo

AU - Zhang, Li

AU - Medina, Aharon

AU - Andrews, Mark L.

AU - Timothy, Katherine

PY - 1999/10/15

Y1 - 1999/10/15

N2 - Acute auditory stimuli and swimming activities are frequently associated with syncope, aborted cardiac arrest, and death in the long QT syndrome (LQTS). We investigated the clinical and genetic findings associated with cardiac events precipitated by these arousal factors. The study population involved 195 patients with an index cardiac event associated with a loud noise (n = 77) or swimming activity (n = 118). Patients with events associated with loud auditory stimuli were older at their index event and were more likely to be women than patients who experienced events during swimming-related activities. Patients with an index event associated with loud noise were likely to have subsequent events related to auditory stimuli; patients with an index event associated with swimming were likely to have recurrent events related to swimming or physical activities. Family patterning of auditory and swimming and/or physical activity-related events was evident. Genotype analyses in 25 patients revealed a significant difference in the distribution of index cardiac events by genotype (p <0.001), with all 19 patients with swimming-related episodes associated with LQT1 genotype and 5 of 6 patients with auditory-related events associated with LQT2 genotype. The clinical profile and genotype findings of patients with LQTS who experience cardiac events related to acute auditory stimuli are quite different from those who experience events accompanying swimming activities.

AB - Acute auditory stimuli and swimming activities are frequently associated with syncope, aborted cardiac arrest, and death in the long QT syndrome (LQTS). We investigated the clinical and genetic findings associated with cardiac events precipitated by these arousal factors. The study population involved 195 patients with an index cardiac event associated with a loud noise (n = 77) or swimming activity (n = 118). Patients with events associated with loud auditory stimuli were older at their index event and were more likely to be women than patients who experienced events during swimming-related activities. Patients with an index event associated with loud noise were likely to have subsequent events related to auditory stimuli; patients with an index event associated with swimming were likely to have recurrent events related to swimming or physical activities. Family patterning of auditory and swimming and/or physical activity-related events was evident. Genotype analyses in 25 patients revealed a significant difference in the distribution of index cardiac events by genotype (p <0.001), with all 19 patients with swimming-related episodes associated with LQT1 genotype and 5 of 6 patients with auditory-related events associated with LQT2 genotype. The clinical profile and genotype findings of patients with LQTS who experience cardiac events related to acute auditory stimuli are quite different from those who experience events accompanying swimming activities.

UR - http://www.scopus.com/inward/record.url?scp=0032874978&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032874978&partnerID=8YFLogxK

U2 - 10.1016/S0002-9149(99)00458-0

DO - 10.1016/S0002-9149(99)00458-0

M3 - Article

C2 - 10532503

AN - SCOPUS:0032874978

VL - 84

SP - 876

EP - 879

JO - American Journal of Cardiology

JF - American Journal of Cardiology

SN - 0002-9149

IS - 8

ER -