Comparison of IL-8, IL-6 and PGE2 formation by visceral (omental) adipose tissue of obese caucasian compared to African-American women

Atul K. Madan, David S. Tichansky, Mathilda Coday, John N. Fain

Research output: Contribution to journalArticle

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Abstract

Background: One of the key consequences of obesity is an enhanced release of cytokines such as IL-8 and IL-6 by adipose tissue. There may be differences in adiposity, inflammatory markers, and medical co-morbidity between morbidly obese African-American (AA) and Caucasian (CA) women. We hypothesized that there are ethnic differences in inflammatory markers and medical co-morbidities. Methods: We compared the mRNA content in omental fat and the release of IL-8, IL-6 and PGE2 after a 4-hour incubation of explants of adipose tissue in women undergoing bariatric surgery. In addition, medical co-morbidities and fat measurements were examined and compared. Results: Medication usage differed, with CA women being three times more likely to report taking medication for depression compared to AA women (P≤0.001). IL-8 and PGE2 release over 4 hours by omental fat in vitro was the same in CA and AA women. Similar results were seen with respect to the COX-2 mRNA and IL-8 mRNA values at the start and at the end of the incubation. In CA and AA women, the IL-6 mRNA content in fat immediately after removal from the patients was the same. Conclusions: In morbidly obese women seeking bariatric surgery, there are little ethnic differences between cytokine release by omental adipose tissue explants in vitro, or the mRNA content in omental adipose tissue of IL-6, IL-8 or COX-2. The only noted difference between AA and CA morbidly obese women was the greater use of antidepressants by CA women.

Original languageEnglish (US)
Pages (from-to)1342-1350
Number of pages9
JournalObesity Surgery
Volume16
Issue number10
DOIs
StatePublished - Oct 1 2006

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Intra-Abdominal Fat
Interleukin-8
Dinoprostone
African Americans
Interleukin-6
Adipose Tissue
Messenger RNA
Fats
Bariatric Surgery
Morbidity
Cytokines
Adiposity
Antidepressive Agents
Obesity

All Science Journal Classification (ASJC) codes

  • Surgery
  • Endocrinology, Diabetes and Metabolism
  • Nutrition and Dietetics

Cite this

Comparison of IL-8, IL-6 and PGE2 formation by visceral (omental) adipose tissue of obese caucasian compared to African-American women. / Madan, Atul K.; Tichansky, David S.; Coday, Mathilda; Fain, John N.

In: Obesity Surgery, Vol. 16, No. 10, 01.10.2006, p. 1342-1350.

Research output: Contribution to journalArticle

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