Comparison of immune response to the influenza vaccine in obese and nonobese healthcare workers

Michael A. Sweet, Jonathan Mccullers, Paul R. Lasala, Frank E. Briggs, Anne Smithmyer, Rashida A. Khakoo

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

objective. To determine whether there is a difference in antibody titers and functionality after receipt of the influenza vaccine for obese versus nonobese healthcare workers (HCW). design. Prospective observational study. setting. Tertiary medical center. participants. Healthcare workers. methods. Baseline influenza antibody titers for obese and nonobese HCW were recorded during the hospital’s 2011 annual influenza vaccination day and follow-up antibody titers were measured 4 weeks later. Antibodies were measured using the hemagglutination inhibition assay and functionality was measured using the micro-neutralization method. results. Of 200 initial HCWs, 190 completed the study (97 obese and 93 nonobese). Seroprotection after immunization was not significantly different for nonobese compared with obese HCW for each strain (influenza A [H1N1], 99% and 99%; influenza A [H3N2], 100% and 99%; and influenza B, 67% and 71%, respectively). All geometric mean titers measured by micro-neutralization showed statistically significant increases in activity. In comparison, there was no difference in the 4-fold increase in H1N1 or B titers. There was a significant difference in the 4-fold increase of H3N2 titers between the nonobese and obese HCWs (82/93 [88%] vs 64/97 [66%], P=.003). In an ad hoc analysis we found that obese HCWs had a statistically greater number of 4-fold decreases in titers with H1N1 and H3N2. conclusions. There was no significant difference in protection from influenza between obese and nonobese HCWs after immunization.

Original languageEnglish (US)
Pages (from-to)249-253
Number of pages5
JournalInfection Control and Hospital Epidemiology
Volume36
Issue number3
DOIs
StatePublished - Mar 1 2015
Externally publishedYes

Fingerprint

Influenza Vaccines
Human Influenza
Delivery of Health Care
Antibodies
Immunization
Hemagglutination
Observational Studies
Vaccination
Prospective Studies

All Science Journal Classification (ASJC) codes

  • Epidemiology
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Comparison of immune response to the influenza vaccine in obese and nonobese healthcare workers. / Sweet, Michael A.; Mccullers, Jonathan; Lasala, Paul R.; Briggs, Frank E.; Smithmyer, Anne; Khakoo, Rashida A.

In: Infection Control and Hospital Epidemiology, Vol. 36, No. 3, 01.03.2015, p. 249-253.

Research output: Contribution to journalArticle

Sweet, Michael A. ; Mccullers, Jonathan ; Lasala, Paul R. ; Briggs, Frank E. ; Smithmyer, Anne ; Khakoo, Rashida A. / Comparison of immune response to the influenza vaccine in obese and nonobese healthcare workers. In: Infection Control and Hospital Epidemiology. 2015 ; Vol. 36, No. 3. pp. 249-253.
@article{f055c48662064813b87c2d5df3636419,
title = "Comparison of immune response to the influenza vaccine in obese and nonobese healthcare workers",
abstract = "objective. To determine whether there is a difference in antibody titers and functionality after receipt of the influenza vaccine for obese versus nonobese healthcare workers (HCW). design. Prospective observational study. setting. Tertiary medical center. participants. Healthcare workers. methods. Baseline influenza antibody titers for obese and nonobese HCW were recorded during the hospital’s 2011 annual influenza vaccination day and follow-up antibody titers were measured 4 weeks later. Antibodies were measured using the hemagglutination inhibition assay and functionality was measured using the micro-neutralization method. results. Of 200 initial HCWs, 190 completed the study (97 obese and 93 nonobese). Seroprotection after immunization was not significantly different for nonobese compared with obese HCW for each strain (influenza A [H1N1], 99{\%} and 99{\%}; influenza A [H3N2], 100{\%} and 99{\%}; and influenza B, 67{\%} and 71{\%}, respectively). All geometric mean titers measured by micro-neutralization showed statistically significant increases in activity. In comparison, there was no difference in the 4-fold increase in H1N1 or B titers. There was a significant difference in the 4-fold increase of H3N2 titers between the nonobese and obese HCWs (82/93 [88{\%}] vs 64/97 [66{\%}], P=.003). In an ad hoc analysis we found that obese HCWs had a statistically greater number of 4-fold decreases in titers with H1N1 and H3N2. conclusions. There was no significant difference in protection from influenza between obese and nonobese HCWs after immunization.",
author = "Sweet, {Michael A.} and Jonathan Mccullers and Lasala, {Paul R.} and Briggs, {Frank E.} and Anne Smithmyer and Khakoo, {Rashida A.}",
year = "2015",
month = "3",
day = "1",
doi = "10.1017/ice.2014.59",
language = "English (US)",
volume = "36",
pages = "249--253",
journal = "Infection Control and Hospital Epidemiology",
issn = "0899-823X",
publisher = "University of Chicago Press",
number = "3",

}

TY - JOUR

T1 - Comparison of immune response to the influenza vaccine in obese and nonobese healthcare workers

AU - Sweet, Michael A.

AU - Mccullers, Jonathan

AU - Lasala, Paul R.

AU - Briggs, Frank E.

AU - Smithmyer, Anne

AU - Khakoo, Rashida A.

PY - 2015/3/1

Y1 - 2015/3/1

N2 - objective. To determine whether there is a difference in antibody titers and functionality after receipt of the influenza vaccine for obese versus nonobese healthcare workers (HCW). design. Prospective observational study. setting. Tertiary medical center. participants. Healthcare workers. methods. Baseline influenza antibody titers for obese and nonobese HCW were recorded during the hospital’s 2011 annual influenza vaccination day and follow-up antibody titers were measured 4 weeks later. Antibodies were measured using the hemagglutination inhibition assay and functionality was measured using the micro-neutralization method. results. Of 200 initial HCWs, 190 completed the study (97 obese and 93 nonobese). Seroprotection after immunization was not significantly different for nonobese compared with obese HCW for each strain (influenza A [H1N1], 99% and 99%; influenza A [H3N2], 100% and 99%; and influenza B, 67% and 71%, respectively). All geometric mean titers measured by micro-neutralization showed statistically significant increases in activity. In comparison, there was no difference in the 4-fold increase in H1N1 or B titers. There was a significant difference in the 4-fold increase of H3N2 titers between the nonobese and obese HCWs (82/93 [88%] vs 64/97 [66%], P=.003). In an ad hoc analysis we found that obese HCWs had a statistically greater number of 4-fold decreases in titers with H1N1 and H3N2. conclusions. There was no significant difference in protection from influenza between obese and nonobese HCWs after immunization.

AB - objective. To determine whether there is a difference in antibody titers and functionality after receipt of the influenza vaccine for obese versus nonobese healthcare workers (HCW). design. Prospective observational study. setting. Tertiary medical center. participants. Healthcare workers. methods. Baseline influenza antibody titers for obese and nonobese HCW were recorded during the hospital’s 2011 annual influenza vaccination day and follow-up antibody titers were measured 4 weeks later. Antibodies were measured using the hemagglutination inhibition assay and functionality was measured using the micro-neutralization method. results. Of 200 initial HCWs, 190 completed the study (97 obese and 93 nonobese). Seroprotection after immunization was not significantly different for nonobese compared with obese HCW for each strain (influenza A [H1N1], 99% and 99%; influenza A [H3N2], 100% and 99%; and influenza B, 67% and 71%, respectively). All geometric mean titers measured by micro-neutralization showed statistically significant increases in activity. In comparison, there was no difference in the 4-fold increase in H1N1 or B titers. There was a significant difference in the 4-fold increase of H3N2 titers between the nonobese and obese HCWs (82/93 [88%] vs 64/97 [66%], P=.003). In an ad hoc analysis we found that obese HCWs had a statistically greater number of 4-fold decreases in titers with H1N1 and H3N2. conclusions. There was no significant difference in protection from influenza between obese and nonobese HCWs after immunization.

UR - http://www.scopus.com/inward/record.url?scp=84923379257&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84923379257&partnerID=8YFLogxK

U2 - 10.1017/ice.2014.59

DO - 10.1017/ice.2014.59

M3 - Article

VL - 36

SP - 249

EP - 253

JO - Infection Control and Hospital Epidemiology

JF - Infection Control and Hospital Epidemiology

SN - 0899-823X

IS - 3

ER -