Comparison of multidose and single-dose methotrexate protocols for the treatment of ectopic pregnancy

Gary H. Lipscomb, Vanessa M. Givens, Norman Meyer, Derita Bran, Stanley Zinberg

Research output: Contribution to journalArticle

64 Citations (Scopus)

Abstract

Objective: The purpose of this study was to compare success rates of 643 patients who had ectopic pregnancy from the same database who were treated with multidose or single-dose methotrexate protocols. Study design: We compared demographics, gestational age, serum human chorionic gonadotropin, progesterone levels, ectopic sac size and volume, overall ectopic mass size and volume, ectopic cardiac activity, history of ectopic pregnancy, number of treatment days, methotrexate doses, and outcome in consecutive patients with ectopic pregnancy who were treated with methotrexate. Results: Success rates were comparable between patients with multidose and single-dose therapy (95% vs 90%, respectively) as were human chorionic gonadotropin and progesterone levels, history of ectopic pregnancy (21.4% vs 21.7%, respectively), number of treatment days, gestational age, ectopic size, ectopic volume, and ectopic mass volume. Patients who received single-dose therapy were significantly heavier (146 vs 159 pounds), had greater ectopic cardiac activity (3.1% vs 10.3%), and received fewer methotrexate doses. Conclusion: This study suggests single-dose methotrexate therapy is as effective as multidose methotrexate therapy for the treatment of ectopic pregnancy.

Original languageEnglish (US)
Pages (from-to)1844-1847
Number of pages4
JournalAmerican Journal of Obstetrics and Gynecology
Volume192
Issue number6
DOIs
StatePublished - Jan 1 2005

Fingerprint

Ectopic Pregnancy
Clinical Protocols
Methotrexate
Chorionic Gonadotropin
Therapeutics
Gestational Age
Progesterone
Cardiac Volume
Demography
Databases
Serum

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Comparison of multidose and single-dose methotrexate protocols for the treatment of ectopic pregnancy. / Lipscomb, Gary H.; Givens, Vanessa M.; Meyer, Norman; Bran, Derita; Zinberg, Stanley.

In: American Journal of Obstetrics and Gynecology, Vol. 192, No. 6, 01.01.2005, p. 1844-1847.

Research output: Contribution to journalArticle

Lipscomb, Gary H. ; Givens, Vanessa M. ; Meyer, Norman ; Bran, Derita ; Zinberg, Stanley. / Comparison of multidose and single-dose methotrexate protocols for the treatment of ectopic pregnancy. In: American Journal of Obstetrics and Gynecology. 2005 ; Vol. 192, No. 6. pp. 1844-1847.
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