Comparison of neurotensin levels, receptors and actions in LS/Ibg and SS/Ibg mice

V. Gene Erwin, Byron Jones

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Neurotensin (NT), injected centrally, markedly enhances sensitivity to ethanol-induced anesthesia in SS but not in LS mice (4). Since LS and SS mice were bred selectively for differential sensitivity to ethanol, these findings suggest that neurotensinergic neuronal processes mediate some of ethanol's actions and that LS and SS mice might differ genetically in neurotensinergic systems. Indeed, in biochemical studies it was shown that LS and SS mice differ in NT-like immunoreactivity in specific brain regions, i.e., hypothalamus, and in NT receptor densities (Bmax) in frontal cortex and striatum. In other experiments LS and SS mice differed in behavioral responses to centrally administered NT. Intracerebroventricular (ICV) administration of NT produced dose-dependent changes in motor activity, hypothermia, and analgesia in both LS and SS mice. SS mice appeared to be more sensitive than LS to NT-induced analgesia but not hypothermia. Neurotensin increased or decreased locomotor activity in both SS and LS mice following intraventral tegmental area or ICV administration, respectively. The results indicate that LS and SS mice, which were selectively bred for differences in ethanol sensitivity, differ genetically in NT concentrations, receptor densities in specific brain regions, and in some receptor-mediated behavioral responses to NT.

Original languageEnglish (US)
Pages (from-to)435-440
Number of pages6
JournalPeptides
Volume10
Issue number2
DOIs
StatePublished - Jan 1 1989

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Neurotensin Receptors
Neurotensin
Ethanol
Hypothermia
Brain
Analgesia
Frontal Lobe
Locomotion
Hypothalamus
Motor Activity
Anesthesia

All Science Journal Classification (ASJC) codes

  • Physiology
  • Biochemistry
  • Endocrinology
  • Cellular and Molecular Neuroscience

Cite this

Comparison of neurotensin levels, receptors and actions in LS/Ibg and SS/Ibg mice. / Gene Erwin, V.; Jones, Byron.

In: Peptides, Vol. 10, No. 2, 01.01.1989, p. 435-440.

Research output: Contribution to journalArticle

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