Comparison of PET measurement of local brain glucose metabolism and CAT measurement of brain atrophy in chronic schizophrenia and depression

A. S. Kling, E. Metter, W. H. Riege, D. E. Kuhl

Research output: Contribution to journalArticle

102 Citations (Scopus)

Abstract

Using [18F]fluorodeoxyglucose and positron emission tomography (PET), the authors examined the regional brain glucose metabolism of six patients with chronic schizophrenia, six patients with chronic depression, and 12 normal control subjects. Three schizophrenic and four depressive patients had CAT scans that showed enlarged ventricles (ventricle-brain ratios higher than 9.0) and widened sylvian fissures. The PET scans of the schizophrenic and depressed patients did not differ significantly from those of the age-matched controls, and a previously reported metabolic 'hypofrontality' was not confirmed. The patients with enlarged ventricles and widened sylvian fissures tended to have lower global metabolism.

Original languageEnglish (US)
Pages (from-to)175-180
Number of pages6
JournalAmerican Journal of Psychiatry
Volume143
Issue number2
DOIs
StatePublished - Jan 1 1986
Externally publishedYes

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Positron-Emission Tomography
Atrophy
Schizophrenia
Depression
Glucose
Brain
Fluorodeoxyglucose F18

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

Cite this

Comparison of PET measurement of local brain glucose metabolism and CAT measurement of brain atrophy in chronic schizophrenia and depression. / Kling, A. S.; Metter, E.; Riege, W. H.; Kuhl, D. E.

In: American Journal of Psychiatry, Vol. 143, No. 2, 01.01.1986, p. 175-180.

Research output: Contribution to journalArticle

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