Comparison of right and left ventricular function and size in Duchenne muscular dystrophy

Muddassir Mehmood, Kan N. Hor, Hussein R. Al-Khalidi, D. Woodrow Benson, John Jefferies, Michael D. Taylor, Gregory F. Egnaczyk, Subha V. Raman, Sanmit K. Basu, Linda H. Cripe, Joshua Germann, Wojciech Mazur

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Introduction Right ventricular (RV) size and function in Duchenne muscular dystrophy (DMD) have not been well described. Using cardiac magnetic resonance (CMR) imaging we describe the relationship of RV and left ventricular (LV) size and function in a large DMD cohort. Methods Latest CMR scans of 272 patients consecutively seen at a single tertiary referral center (2011-2014) with skeletal muscle biopsy confirmed DMD were included. 1.5 and 3 Tesla CMR scanners were used. Biventricular ejection fraction (EF), end-diastolic volume index (EDVI), mass and mass index were compared across categories of LVEF. Results Mean age was 13.5 ± 4.9 years. 71% had normal (≥55%) LVEF while mild (EF 45-54%), moderate (EF 30-44%), and severe LV dysfunction (EF <30%) was present in 20%, 6% and 3% respectively. The correlation between RVEF and LVEF was weak. Even in patients with severe LV dysfunction, RVEF (49.7% ± 12.9%) was relatively preserved. There were no significant differences in RVEDVI and RV mass index across categories of LV function. Conclusion In a large DMD cohort, RVEF was relatively preserved and RV size was preserved across categories of LV dysfunction.

Original languageEnglish (US)
Pages (from-to)1938-1942
Number of pages5
JournalEuropean Journal of Radiology
Volume84
Issue number10
DOIs
StatePublished - Oct 1 2015

Fingerprint

Right Ventricular Function
Duchenne Muscular Dystrophy
Left Ventricular Function
Left Ventricular Dysfunction
Magnetic Resonance Spectroscopy
Tertiary Care Centers
Stroke Volume
Skeletal Muscle
Magnetic Resonance Imaging
Biopsy

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Mehmood, M., Hor, K. N., Al-Khalidi, H. R., Benson, D. W., Jefferies, J., Taylor, M. D., ... Mazur, W. (2015). Comparison of right and left ventricular function and size in Duchenne muscular dystrophy. European Journal of Radiology, 84(10), 1938-1942. https://doi.org/10.1016/j.ejrad.2015.07.007

Comparison of right and left ventricular function and size in Duchenne muscular dystrophy. / Mehmood, Muddassir; Hor, Kan N.; Al-Khalidi, Hussein R.; Benson, D. Woodrow; Jefferies, John; Taylor, Michael D.; Egnaczyk, Gregory F.; Raman, Subha V.; Basu, Sanmit K.; Cripe, Linda H.; Germann, Joshua; Mazur, Wojciech.

In: European Journal of Radiology, Vol. 84, No. 10, 01.10.2015, p. 1938-1942.

Research output: Contribution to journalArticle

Mehmood, M, Hor, KN, Al-Khalidi, HR, Benson, DW, Jefferies, J, Taylor, MD, Egnaczyk, GF, Raman, SV, Basu, SK, Cripe, LH, Germann, J & Mazur, W 2015, 'Comparison of right and left ventricular function and size in Duchenne muscular dystrophy', European Journal of Radiology, vol. 84, no. 10, pp. 1938-1942. https://doi.org/10.1016/j.ejrad.2015.07.007
Mehmood, Muddassir ; Hor, Kan N. ; Al-Khalidi, Hussein R. ; Benson, D. Woodrow ; Jefferies, John ; Taylor, Michael D. ; Egnaczyk, Gregory F. ; Raman, Subha V. ; Basu, Sanmit K. ; Cripe, Linda H. ; Germann, Joshua ; Mazur, Wojciech. / Comparison of right and left ventricular function and size in Duchenne muscular dystrophy. In: European Journal of Radiology. 2015 ; Vol. 84, No. 10. pp. 1938-1942.
@article{a3ea2fd2d141410da25ffd50224dadaf,
title = "Comparison of right and left ventricular function and size in Duchenne muscular dystrophy",
abstract = "Introduction Right ventricular (RV) size and function in Duchenne muscular dystrophy (DMD) have not been well described. Using cardiac magnetic resonance (CMR) imaging we describe the relationship of RV and left ventricular (LV) size and function in a large DMD cohort. Methods Latest CMR scans of 272 patients consecutively seen at a single tertiary referral center (2011-2014) with skeletal muscle biopsy confirmed DMD were included. 1.5 and 3 Tesla CMR scanners were used. Biventricular ejection fraction (EF), end-diastolic volume index (EDVI), mass and mass index were compared across categories of LVEF. Results Mean age was 13.5 ± 4.9 years. 71{\%} had normal (≥55{\%}) LVEF while mild (EF 45-54{\%}), moderate (EF 30-44{\%}), and severe LV dysfunction (EF <30{\%}) was present in 20{\%}, 6{\%} and 3{\%} respectively. The correlation between RVEF and LVEF was weak. Even in patients with severe LV dysfunction, RVEF (49.7{\%} ± 12.9{\%}) was relatively preserved. There were no significant differences in RVEDVI and RV mass index across categories of LV function. Conclusion In a large DMD cohort, RVEF was relatively preserved and RV size was preserved across categories of LV dysfunction.",
author = "Muddassir Mehmood and Hor, {Kan N.} and Al-Khalidi, {Hussein R.} and Benson, {D. Woodrow} and John Jefferies and Taylor, {Michael D.} and Egnaczyk, {Gregory F.} and Raman, {Subha V.} and Basu, {Sanmit K.} and Cripe, {Linda H.} and Joshua Germann and Wojciech Mazur",
year = "2015",
month = "10",
day = "1",
doi = "10.1016/j.ejrad.2015.07.007",
language = "English (US)",
volume = "84",
pages = "1938--1942",
journal = "European Journal of Radiology",
issn = "0720-048X",
publisher = "Elsevier Ireland Ltd",
number = "10",

}

TY - JOUR

T1 - Comparison of right and left ventricular function and size in Duchenne muscular dystrophy

AU - Mehmood, Muddassir

AU - Hor, Kan N.

AU - Al-Khalidi, Hussein R.

AU - Benson, D. Woodrow

AU - Jefferies, John

AU - Taylor, Michael D.

AU - Egnaczyk, Gregory F.

AU - Raman, Subha V.

AU - Basu, Sanmit K.

AU - Cripe, Linda H.

AU - Germann, Joshua

AU - Mazur, Wojciech

PY - 2015/10/1

Y1 - 2015/10/1

N2 - Introduction Right ventricular (RV) size and function in Duchenne muscular dystrophy (DMD) have not been well described. Using cardiac magnetic resonance (CMR) imaging we describe the relationship of RV and left ventricular (LV) size and function in a large DMD cohort. Methods Latest CMR scans of 272 patients consecutively seen at a single tertiary referral center (2011-2014) with skeletal muscle biopsy confirmed DMD were included. 1.5 and 3 Tesla CMR scanners were used. Biventricular ejection fraction (EF), end-diastolic volume index (EDVI), mass and mass index were compared across categories of LVEF. Results Mean age was 13.5 ± 4.9 years. 71% had normal (≥55%) LVEF while mild (EF 45-54%), moderate (EF 30-44%), and severe LV dysfunction (EF <30%) was present in 20%, 6% and 3% respectively. The correlation between RVEF and LVEF was weak. Even in patients with severe LV dysfunction, RVEF (49.7% ± 12.9%) was relatively preserved. There were no significant differences in RVEDVI and RV mass index across categories of LV function. Conclusion In a large DMD cohort, RVEF was relatively preserved and RV size was preserved across categories of LV dysfunction.

AB - Introduction Right ventricular (RV) size and function in Duchenne muscular dystrophy (DMD) have not been well described. Using cardiac magnetic resonance (CMR) imaging we describe the relationship of RV and left ventricular (LV) size and function in a large DMD cohort. Methods Latest CMR scans of 272 patients consecutively seen at a single tertiary referral center (2011-2014) with skeletal muscle biopsy confirmed DMD were included. 1.5 and 3 Tesla CMR scanners were used. Biventricular ejection fraction (EF), end-diastolic volume index (EDVI), mass and mass index were compared across categories of LVEF. Results Mean age was 13.5 ± 4.9 years. 71% had normal (≥55%) LVEF while mild (EF 45-54%), moderate (EF 30-44%), and severe LV dysfunction (EF <30%) was present in 20%, 6% and 3% respectively. The correlation between RVEF and LVEF was weak. Even in patients with severe LV dysfunction, RVEF (49.7% ± 12.9%) was relatively preserved. There were no significant differences in RVEDVI and RV mass index across categories of LV function. Conclusion In a large DMD cohort, RVEF was relatively preserved and RV size was preserved across categories of LV dysfunction.

UR - http://www.scopus.com/inward/record.url?scp=84941801631&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84941801631&partnerID=8YFLogxK

U2 - 10.1016/j.ejrad.2015.07.007

DO - 10.1016/j.ejrad.2015.07.007

M3 - Article

VL - 84

SP - 1938

EP - 1942

JO - European Journal of Radiology

JF - European Journal of Radiology

SN - 0720-048X

IS - 10

ER -