Comparison of the Effects of Alpha and Beta Interferons on the Proliferation and Volume of Human Tumor Cells (HeLa-S3, Daudi, P3HR-I)

Lawrence Pfeffer, Igor Tamm

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Treatment of three lines of tumor cells (epidermoid carcinoma: HeLa-S3, and Burkitt's lymphoma: Daudi and P3HR-1) with human alpha or beta interferon (HuIFN-α or HuIFN-β) results in inhibition of cell proliferation as well as in increased modal cell volume and heterogeneity of the populations with respect to cell volume. In all three cell lines the IFN-α- or IFN-β-induced changes in cell proliferation and in cell volume are inversely related to each other. However, these lines differ significantly in their sensitivity to the effects of IFN-α and IFN-β.

Original languageEnglish (US)
Pages (from-to)395-408
Number of pages14
JournalJournal of Interferon Research
Volume3
Issue number4
DOIs
StatePublished - Jan 1 1983
Externally publishedYes

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Interferon-beta
Tumor Burden
Cell Size
HeLa Cells
Interferon-alpha
Cell Proliferation
Burkitt Lymphoma
Population Characteristics
Tumor Cell Line
Squamous Cell Carcinoma
Cell Line

All Science Journal Classification (ASJC) codes

  • Immunology
  • Virology

Cite this

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abstract = "Treatment of three lines of tumor cells (epidermoid carcinoma: HeLa-S3, and Burkitt's lymphoma: Daudi and P3HR-1) with human alpha or beta interferon (HuIFN-α or HuIFN-β) results in inhibition of cell proliferation as well as in increased modal cell volume and heterogeneity of the populations with respect to cell volume. In all three cell lines the IFN-α- or IFN-β-induced changes in cell proliferation and in cell volume are inversely related to each other. However, these lines differ significantly in their sensitivity to the effects of IFN-α and IFN-β.",
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T1 - Comparison of the Effects of Alpha and Beta Interferons on the Proliferation and Volume of Human Tumor Cells (HeLa-S3, Daudi, P3HR-I)

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AU - Tamm, Igor

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AB - Treatment of three lines of tumor cells (epidermoid carcinoma: HeLa-S3, and Burkitt's lymphoma: Daudi and P3HR-1) with human alpha or beta interferon (HuIFN-α or HuIFN-β) results in inhibition of cell proliferation as well as in increased modal cell volume and heterogeneity of the populations with respect to cell volume. In all three cell lines the IFN-α- or IFN-β-induced changes in cell proliferation and in cell volume are inversely related to each other. However, these lines differ significantly in their sensitivity to the effects of IFN-α and IFN-β.

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