Comparison of the effects of gastric antisecretory agents in healthy volunteers and patients with duodenal ulcer

Colin Howden, D. B. Jones, D. W. Burget, R. H. Hunt

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Thirty published studies of the clinical pharmacology of gastric antisecretory agents in normal volunteers and duodenal ulcer patients were reviewed. The aim was to investigate the relationship between antisecretory effect in the two populations. There was a significant correlation between effect in patients and normal subjects for suppression of 24 hour intragastric acidity (r = 0.732; p = 0.0068), nocturnal intragastric acidity (r = 0.861; p = 0.0033) and nocturnal acid output (r = 0.964; p = 0.0069). The regression lines for 24 hour and nocturnal acidity were very similar. The expected antisecretory effect of a particular dosage regimen in patients with duodenal ulcer can be predicted mathematically from data derived from studies in normal volunteers.

Original languageEnglish (US)
Pages (from-to)1058-1061
Number of pages4
JournalGut
Volume27
Issue number9
DOIs
StatePublished - Jan 1 1986

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Gastrointestinal Agents
Duodenal Ulcer
Healthy Volunteers
Clinical Pharmacology
Acids
Population

All Science Journal Classification (ASJC) codes

  • Gastroenterology

Cite this

Comparison of the effects of gastric antisecretory agents in healthy volunteers and patients with duodenal ulcer. / Howden, Colin; Jones, D. B.; Burget, D. W.; Hunt, R. H.

In: Gut, Vol. 27, No. 9, 01.01.1986, p. 1058-1061.

Research output: Contribution to journalArticle

Howden, Colin ; Jones, D. B. ; Burget, D. W. ; Hunt, R. H. / Comparison of the effects of gastric antisecretory agents in healthy volunteers and patients with duodenal ulcer. In: Gut. 1986 ; Vol. 27, No. 9. pp. 1058-1061.
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