Comparison of tolerance and nutritional outcome between a peptide and a standard enteral formula in critically ill, hypoalbuminemic patients

C. A. Mowatt-Larssen, R. O. Brown, S. L. Wojtysiak, K. A. Kudsk

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Dipeptides have been reported to be more efficiently absorbed from the gastrointestinal tract than free amino acids. The objective of this study was to compare prospectively a peptide enteral formula (PEF) with a standard enteral formula (SEF) for tolerance and nutritional outcome in acutely injured, hypoalbuminemic (<3.0 g/dL) patients who require enteral nutrition support. The prevalence of diarrhea and elevated gastric residuals was assessed daily. Prealbumin, transferrin, colloid oncotic pressure, Prognostic Nutritional Index, and nitrogen balance were measured on days 0, 5, and 10 of enteral nutrition support. Forty-one patients received 345 days of enteral nutrition support. Prevalences of diarrhea and elevated gastric residuals were similar between groups. Prealbumin increased and the Prognostic Nutritional Index decreased significantly from baseline at day 10 in both groups. Transferrin increased in both groups, but not significantly. Colloid oncotic pressure increased significantly from baseline at days 5 and 10 in the SEF group and day 10 in the PEF group. Nitrogen balance increased significantly from baseline at days 5 and 10 in each group. The only significant difference between groups was for nitrogen balance at day 10, which was higher in the SEF group. We conclude based upon our selected measurements of tolerance and nutritional outcome PEF seams to offer no advantage over SEF in acutely injured, hypoalbuminemic patients.

Original languageEnglish (US)
Pages (from-to)20-24
Number of pages5
JournalJournal of Parenteral and Enteral Nutrition
Volume16
Issue number1
DOIs
StatePublished - Jan 1 1992

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Critical Illness
Small Intestine
Peptides
Enteral Nutrition
Nutrition Assessment
Prealbumin
Nitrogen
Colloids
Transferrin
Diarrhea
Stomach
Pressure
Dipeptides
Gastrointestinal Tract
Amino Acids

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Comparison of tolerance and nutritional outcome between a peptide and a standard enteral formula in critically ill, hypoalbuminemic patients. / Mowatt-Larssen, C. A.; Brown, R. O.; Wojtysiak, S. L.; Kudsk, K. A.

In: Journal of Parenteral and Enteral Nutrition, Vol. 16, No. 1, 01.01.1992, p. 20-24.

Research output: Contribution to journalArticle

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