Compartmentalization of cyclic nucleotide signaling

A question of when, where, and why?

Kavisha Arora, Chandrima Sinha, Weiqiang Zhang, Aixia Ren, Chang Suk Moon, Sunitha Yarlagadda, Anjaparavanda P. Naren

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Preciseness of cellular behavior depends upon how an extracellular cue mobilizes a correct orchestra of cellular messengers and effector proteins spatially and temporally. This concept, termed compartmentalization of cellular signaling, is now known to form the molecular basis of many aspects of cellular behavior in health and disease. The cyclic nucleotides cyclic adenosine monophosphate and cyclic guanosine monophosphate are ubiquitous cellular messengers that can be compartmentalized in three ways: first, by their physical containment; second, by formation of multiple protein signaling complexes; and third, by their selective depletion. Compartmentalized cyclic nucleotide signaling is a very prevalent response among all cell types. In order to understand how it becomes relevant to cellular behavior, it is important to know how it is executed in cells to regulate physiological responses and, also, how its execution or dysregulation can lead to a pathophysiological condition, which forms the scope of the presented review.

Original languageEnglish (US)
Pages (from-to)1397-1407
Number of pages11
JournalPflugers Archiv European Journal of Physiology
Volume465
Issue number10
DOIs
StatePublished - Oct 1 2013

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Cyclic Nucleotides
Cell signaling
Containment of Biohazards
Cues
Proteins
Health
cyclic guanosine monophosphate-adenosine monophosphate

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Biochemistry
  • Physiology (medical)

Cite this

Compartmentalization of cyclic nucleotide signaling : A question of when, where, and why? / Arora, Kavisha; Sinha, Chandrima; Zhang, Weiqiang; Ren, Aixia; Moon, Chang Suk; Yarlagadda, Sunitha; Naren, Anjaparavanda P.

In: Pflugers Archiv European Journal of Physiology, Vol. 465, No. 10, 01.10.2013, p. 1397-1407.

Research output: Contribution to journalReview article

Arora, Kavisha ; Sinha, Chandrima ; Zhang, Weiqiang ; Ren, Aixia ; Moon, Chang Suk ; Yarlagadda, Sunitha ; Naren, Anjaparavanda P. / Compartmentalization of cyclic nucleotide signaling : A question of when, where, and why?. In: Pflugers Archiv European Journal of Physiology. 2013 ; Vol. 465, No. 10. pp. 1397-1407.
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