Compulsive sucrose- and cocaine-seeking behaviors in male and female Wistar rats

Udita Datta, Mariangela Martini, Meiyun Fan, Wen Lin Sun

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Rationale: Compulsive cocaine use is a key feature of cocaine addiction and understanding the factors that promote the development of such a behavior will provide important insights into the mechanism of cocaine addiction and is essential for the clinical management of the disorder. Objectives: This study aimed to determine how the preexisting compulsive reward-seeking behavior is related to the development of compulsive cocaine-seeking behavior in male and female rats and the potential impact of the reward value and estrous cycle on such behaviors. Methods: Adult male and female Wistar rats were first trained to self-administer sucrose pellets under a chained schedule, and then, the intensity-response effects of footshock punishment on sucrose SA reinforced by different values of sucrose were measured. Subsequently, the same rats went on to self-administer intravenous cocaine and the punishment intensity-response effects on cocaine SA reinforced by different doses of cocaine were similarly determined. For the female rats, the measurements were made during different phases of the estrous cycle. Results: The rats showed a wide range of levels of the compulsive behaviors despite the similar training history. Surprisingly, the compulsive sucrose-seeking behavior did not predict the compulsive cocaine-seeking behavior in either sex. Increasing cocaine dose significantly increased the compulsive cocaine-seeking behavior in the female but not male rats. Estrous cycle did not have impact on the compulsive behaviors. Conclusion: Preexisting differences in compulsive sucrose-seeking behavior do not predict compulsive cocaine-seeking behavior. Compulsive cocaine-seeking behavior is influenced by cocaine dose but not estrous cycle in the female rats.

Original languageEnglish (US)
Pages (from-to)2395-2405
Number of pages11
JournalPsychopharmacology
Volume235
Issue number8
DOIs
StatePublished - Aug 1 2018

Fingerprint

Cocaine
Sucrose
Wistar Rats
Estrous Cycle
Compulsive Behavior
Cocaine-Related Disorders
Punishment
Reward
Appointments and Schedules
History

All Science Journal Classification (ASJC) codes

  • Pharmacology

Cite this

Compulsive sucrose- and cocaine-seeking behaviors in male and female Wistar rats. / Datta, Udita; Martini, Mariangela; Fan, Meiyun; Sun, Wen Lin.

In: Psychopharmacology, Vol. 235, No. 8, 01.08.2018, p. 2395-2405.

Research output: Contribution to journalArticle

@article{b5c3b7965c164f53b843f201fb351eed,
title = "Compulsive sucrose- and cocaine-seeking behaviors in male and female Wistar rats",
abstract = "Rationale: Compulsive cocaine use is a key feature of cocaine addiction and understanding the factors that promote the development of such a behavior will provide important insights into the mechanism of cocaine addiction and is essential for the clinical management of the disorder. Objectives: This study aimed to determine how the preexisting compulsive reward-seeking behavior is related to the development of compulsive cocaine-seeking behavior in male and female rats and the potential impact of the reward value and estrous cycle on such behaviors. Methods: Adult male and female Wistar rats were first trained to self-administer sucrose pellets under a chained schedule, and then, the intensity-response effects of footshock punishment on sucrose SA reinforced by different values of sucrose were measured. Subsequently, the same rats went on to self-administer intravenous cocaine and the punishment intensity-response effects on cocaine SA reinforced by different doses of cocaine were similarly determined. For the female rats, the measurements were made during different phases of the estrous cycle. Results: The rats showed a wide range of levels of the compulsive behaviors despite the similar training history. Surprisingly, the compulsive sucrose-seeking behavior did not predict the compulsive cocaine-seeking behavior in either sex. Increasing cocaine dose significantly increased the compulsive cocaine-seeking behavior in the female but not male rats. Estrous cycle did not have impact on the compulsive behaviors. Conclusion: Preexisting differences in compulsive sucrose-seeking behavior do not predict compulsive cocaine-seeking behavior. Compulsive cocaine-seeking behavior is influenced by cocaine dose but not estrous cycle in the female rats.",
author = "Udita Datta and Mariangela Martini and Meiyun Fan and Sun, {Wen Lin}",
year = "2018",
month = "8",
day = "1",
doi = "10.1007/s00213-018-4937-1",
language = "English (US)",
volume = "235",
pages = "2395--2405",
journal = "Psychopharmacology",
issn = "0033-3158",
publisher = "Springer Verlag",
number = "8",

}

TY - JOUR

T1 - Compulsive sucrose- and cocaine-seeking behaviors in male and female Wistar rats

AU - Datta, Udita

AU - Martini, Mariangela

AU - Fan, Meiyun

AU - Sun, Wen Lin

PY - 2018/8/1

Y1 - 2018/8/1

N2 - Rationale: Compulsive cocaine use is a key feature of cocaine addiction and understanding the factors that promote the development of such a behavior will provide important insights into the mechanism of cocaine addiction and is essential for the clinical management of the disorder. Objectives: This study aimed to determine how the preexisting compulsive reward-seeking behavior is related to the development of compulsive cocaine-seeking behavior in male and female rats and the potential impact of the reward value and estrous cycle on such behaviors. Methods: Adult male and female Wistar rats were first trained to self-administer sucrose pellets under a chained schedule, and then, the intensity-response effects of footshock punishment on sucrose SA reinforced by different values of sucrose were measured. Subsequently, the same rats went on to self-administer intravenous cocaine and the punishment intensity-response effects on cocaine SA reinforced by different doses of cocaine were similarly determined. For the female rats, the measurements were made during different phases of the estrous cycle. Results: The rats showed a wide range of levels of the compulsive behaviors despite the similar training history. Surprisingly, the compulsive sucrose-seeking behavior did not predict the compulsive cocaine-seeking behavior in either sex. Increasing cocaine dose significantly increased the compulsive cocaine-seeking behavior in the female but not male rats. Estrous cycle did not have impact on the compulsive behaviors. Conclusion: Preexisting differences in compulsive sucrose-seeking behavior do not predict compulsive cocaine-seeking behavior. Compulsive cocaine-seeking behavior is influenced by cocaine dose but not estrous cycle in the female rats.

AB - Rationale: Compulsive cocaine use is a key feature of cocaine addiction and understanding the factors that promote the development of such a behavior will provide important insights into the mechanism of cocaine addiction and is essential for the clinical management of the disorder. Objectives: This study aimed to determine how the preexisting compulsive reward-seeking behavior is related to the development of compulsive cocaine-seeking behavior in male and female rats and the potential impact of the reward value and estrous cycle on such behaviors. Methods: Adult male and female Wistar rats were first trained to self-administer sucrose pellets under a chained schedule, and then, the intensity-response effects of footshock punishment on sucrose SA reinforced by different values of sucrose were measured. Subsequently, the same rats went on to self-administer intravenous cocaine and the punishment intensity-response effects on cocaine SA reinforced by different doses of cocaine were similarly determined. For the female rats, the measurements were made during different phases of the estrous cycle. Results: The rats showed a wide range of levels of the compulsive behaviors despite the similar training history. Surprisingly, the compulsive sucrose-seeking behavior did not predict the compulsive cocaine-seeking behavior in either sex. Increasing cocaine dose significantly increased the compulsive cocaine-seeking behavior in the female but not male rats. Estrous cycle did not have impact on the compulsive behaviors. Conclusion: Preexisting differences in compulsive sucrose-seeking behavior do not predict compulsive cocaine-seeking behavior. Compulsive cocaine-seeking behavior is influenced by cocaine dose but not estrous cycle in the female rats.

UR - http://www.scopus.com/inward/record.url?scp=85048543909&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85048543909&partnerID=8YFLogxK

U2 - 10.1007/s00213-018-4937-1

DO - 10.1007/s00213-018-4937-1

M3 - Article

VL - 235

SP - 2395

EP - 2405

JO - Psychopharmacology

JF - Psychopharmacology

SN - 0033-3158

IS - 8

ER -