Congenital cystic hemangioblastomas of the cerebral hemisphere in a neonate without alteration in the VHL gene

Mahlon Johnson, Alex R. Mitchell, E. Christopher Troup, Deb A. Bhowmick, Scott D. Wait, Joseph Aulino, Zhengping Zhuang, Robert J. Weil

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

A 4-week-old child presented with lethargy, emesis, decreased spontaneous movements, and a bulging fontanelle. Neuroimaging demonstrated a large, hemispheric, multicystic lesion with multiple enhancing nodules, which, on pathological examination, proved to be multiple, distinct hemangioblastomas. Careful molecular analysis failed to reveal alterations of the VHL gene. This represents an uncommon presentation for these tumors and suggests that genes other than VHL may be important in the genesis of these tumors.

Original languageEnglish (US)
Pages (from-to)124-127
Number of pages4
JournalPediatric Neurosurgery
Volume40
Issue number3
DOIs
StatePublished - Oct 7 2004

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Hemangioblastoma
Cerebrum
Newborn Infant
Lethargy
Neuroimaging
Genes
Vomiting
Neoplasms

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Surgery
  • Clinical Neurology

Cite this

Johnson, M., Mitchell, A. R., Troup, E. C., Bhowmick, D. A., Wait, S. D., Aulino, J., ... Weil, R. J. (2004). Congenital cystic hemangioblastomas of the cerebral hemisphere in a neonate without alteration in the VHL gene. Pediatric Neurosurgery, 40(3), 124-127. https://doi.org/10.1159/000079854

Congenital cystic hemangioblastomas of the cerebral hemisphere in a neonate without alteration in the VHL gene. / Johnson, Mahlon; Mitchell, Alex R.; Troup, E. Christopher; Bhowmick, Deb A.; Wait, Scott D.; Aulino, Joseph; Zhuang, Zhengping; Weil, Robert J.

In: Pediatric Neurosurgery, Vol. 40, No. 3, 07.10.2004, p. 124-127.

Research output: Contribution to journalArticle

Johnson, M, Mitchell, AR, Troup, EC, Bhowmick, DA, Wait, SD, Aulino, J, Zhuang, Z & Weil, RJ 2004, 'Congenital cystic hemangioblastomas of the cerebral hemisphere in a neonate without alteration in the VHL gene', Pediatric Neurosurgery, vol. 40, no. 3, pp. 124-127. https://doi.org/10.1159/000079854
Johnson, Mahlon ; Mitchell, Alex R. ; Troup, E. Christopher ; Bhowmick, Deb A. ; Wait, Scott D. ; Aulino, Joseph ; Zhuang, Zhengping ; Weil, Robert J. / Congenital cystic hemangioblastomas of the cerebral hemisphere in a neonate without alteration in the VHL gene. In: Pediatric Neurosurgery. 2004 ; Vol. 40, No. 3. pp. 124-127.
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