Congestive heart failure in copper-deficient mice

Laila Elsherif, Raymond V. Ortines, Jack T. Saari, Yujian Kang

Research output: Contribution to journalArticle

45 Citations (Scopus)

Abstract

Copper Deficiency (CuD) leads to hypertrophic cardiomyopathy in various experimental models. The morphological, electrophysiological, and molecular aspects of this hypertrophy have been under investigation for a long time. However the transition from compensated hypertrophy to decompensated heart failure has not been investigated in the study of CuD. We set out to investigate the contractile and hemodynamic parameters of the CuD mouse heart and to determine whether heart failure follows hypertrophy in the CuD heart. Dams of FVB mice were fed CuD or copper-adequate (CuA) diet starting from the third day post delivery and the weanling pups were fed the same diet for a total period of 5 weeks (pre- and postweanling). At week 4, the functional parameters of the heart were analyzed using a surgical technique for catheterizing the left ventricle. A significant decrease in left ventricle systolic pressure was observed with no significant change in heart rate, and more importantly contractility as measured by the maximal rate of left ventricular pressure rise (+dP/dt) and decline (-dP/dt) were significantly depressed in the CuD mice. However, left ventricle end diastolic pressure was elevated, and relaxation was impaired in the CuD animals; the duration of relaxation was prolonged. In addition to significant changes in the basal level of cardiac function, CuD hearts had a blunted response to the stimulation of the β-adrenergic agonist isoproterenol. Furthermore, morphological analysis revealed increased collagen accumulation in the CuD hearts along with lipid deposition. This study shows that CuD leads to systolic and diastolic dysfunction in association with histopathological changes, which are indices commonly used to diagnose congestive heart failure.

Original languageEnglish (US)
Pages (from-to)811-817
Number of pages7
JournalExperimental Biology and Medicine
Volume228
Issue number7
DOIs
StatePublished - Jan 1 2003
Externally publishedYes

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Copper
Heart Failure
Hypertrophy
Heart Ventricles
Diet
Blood Pressure
Adrenergic Agonists
Nutrition
Hypertrophic Cardiomyopathy
Ventricular Pressure
Isoproterenol
Theoretical Models
Collagen
Heart Rate
Hemodynamics
Lipids
Dams
Animals

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Congestive heart failure in copper-deficient mice. / Elsherif, Laila; Ortines, Raymond V.; Saari, Jack T.; Kang, Yujian.

In: Experimental Biology and Medicine, Vol. 228, No. 7, 01.01.2003, p. 811-817.

Research output: Contribution to journalArticle

Elsherif, Laila ; Ortines, Raymond V. ; Saari, Jack T. ; Kang, Yujian. / Congestive heart failure in copper-deficient mice. In: Experimental Biology and Medicine. 2003 ; Vol. 228, No. 7. pp. 811-817.
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