Kon''iugirovanie klassicheskogo soevogo ingibitora tipa Baumana-Birk s sopolimerom okisi étilena i okisi propilena.

Translated title of the contribution: Conjugation of classic Bowman-Birk soy inhibitor with a copolymer of ethylene oxide and propylene oxide

N. I. Larionova, I. P. Gladysheva, I. N. Topchieva, N. F. Kazanskaia

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

A classical soybean inhibitor of the Bowman-Birk type (BBI) with a copolymer of ethylene oxide and propylene oxide (PE) has been synthesized. The BBI-PE conjugate contain five covalently bound polymeric chains per one protein molecule and retains its capacity to inhibit trypsin (Ki = 10(-10) M), alpha-chymotrypsin (Ki = 7 x 10(-8) M) and human granulocyte elastase (Ki = 3 x 10(-8) M). The preservation of the antiproteinase activity in the antichymotrypsin center creates a prerequisite for the manifestation of the anticarcinogenic effect of the inhibitor.

Original languageRussian
Pages (from-to)1658-1664
Number of pages7
JournalBiokhimiya
Volume58
Issue number10
StatePublished - Oct 1993
Externally publishedYes

Fingerprint

UCON 50-HB-5100
Anticarcinogenic Agents
Leukocyte Elastase
Trypsin
Molecules
Proteins
alpha-chymotrypsin
propylene oxide

All Science Journal Classification (ASJC) codes

  • Chemistry(all)

Cite this

Larionova, N. I., Gladysheva, I. P., Topchieva, I. N., & Kazanskaia, N. F. (1993). Kon''iugirovanie klassicheskogo soevogo ingibitora tipa Baumana-Birk s sopolimerom okisi étilena i okisi propilena. Biokhimiya, 58(10), 1658-1664.

Kon''iugirovanie klassicheskogo soevogo ingibitora tipa Baumana-Birk s sopolimerom okisi étilena i okisi propilena. / Larionova, N. I.; Gladysheva, I. P.; Topchieva, I. N.; Kazanskaia, N. F.

In: Biokhimiya, Vol. 58, No. 10, 10.1993, p. 1658-1664.

Research output: Contribution to journalArticle

Larionova, NI, Gladysheva, IP, Topchieva, IN & Kazanskaia, NF 1993, 'Kon''iugirovanie klassicheskogo soevogo ingibitora tipa Baumana-Birk s sopolimerom okisi étilena i okisi propilena.', Biokhimiya, vol. 58, no. 10, pp. 1658-1664.
Larionova NI, Gladysheva IP, Topchieva IN, Kazanskaia NF. Kon''iugirovanie klassicheskogo soevogo ingibitora tipa Baumana-Birk s sopolimerom okisi étilena i okisi propilena. Biokhimiya. 1993 Oct;58(10):1658-1664.
Larionova, N. I. ; Gladysheva, I. P. ; Topchieva, I. N. ; Kazanskaia, N. F. / Kon''iugirovanie klassicheskogo soevogo ingibitora tipa Baumana-Birk s sopolimerom okisi étilena i okisi propilena. In: Biokhimiya. 1993 ; Vol. 58, No. 10. pp. 1658-1664.
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