Conjunctival structure and cell counts and the results of filtering surgery

D. R. Gwynn, W. C. Stewart, R. A. Pitts, Tod Mcmillan, H. L. Hennis

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

We evaluated perioperative conjunctival biopsy specimens in 28 consecutive patients with primary open-angle glaucoma undergoing trabeculectomy who had not undergone previous intraocular surgery. We found six months postoperatively that the number of goblet cells was significantly greater (6.40 ± 5.40 vs 1.68 ± 1.60 per field of view; P = .004, Student's t-test) in patients with easier postoperative intraocular pressure control (intraocular pressure ≤ 15 mm Hg with zero to two glaucoma medications) than in patients with more difficult intraocular pressure control (>15 mm Hg with three or more glaucoma medications). No statistical differences between groups were observed in mast cells, neutrophils, eosinophils, macrophages, plasma cells, lymphocytes, or fibroblasts (P > .05). Also, no statistical difference between groups existed in conjunctival structure, including mucopolysaccharide and collagen composition, vascular density, or epithelial thickness (P > .05). This study suggests that the number of conjunctival goblet cells may be related to intraocular pressure control after trabeculectomy.

Original languageEnglish (US)
Pages (from-to)464-468
Number of pages5
JournalAmerican Journal of Ophthalmology
Volume116
Issue number4
DOIs
StatePublished - Jan 1 1993
Externally publishedYes

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Filtering Surgery
Intraocular Pressure
Cell Count
Trabeculectomy
Goblet Cells
Glaucoma
Plasma Cells
Glycosaminoglycans
Eosinophils
Mast Cells
Blood Vessels
Neutrophils
Collagen
Fibroblasts
Macrophages
Lymphocytes
Students
Biopsy

All Science Journal Classification (ASJC) codes

  • Ophthalmology

Cite this

Conjunctival structure and cell counts and the results of filtering surgery. / Gwynn, D. R.; Stewart, W. C.; Pitts, R. A.; Mcmillan, Tod; Hennis, H. L.

In: American Journal of Ophthalmology, Vol. 116, No. 4, 01.01.1993, p. 464-468.

Research output: Contribution to journalArticle

Gwynn, D. R. ; Stewart, W. C. ; Pitts, R. A. ; Mcmillan, Tod ; Hennis, H. L. / Conjunctival structure and cell counts and the results of filtering surgery. In: American Journal of Ophthalmology. 1993 ; Vol. 116, No. 4. pp. 464-468.
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