Conservative management of pancreatic pseudocysts in children with acute lymphoblastic leukemia

Holly L. Spraker, Georgios P. Spyridis, Ching Hon Pui, Scott Howard

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Treatment with asparaginase for acute lymphoblastic leukemia can cause acute pancreatitis. Complication of pancreatitis by pancreatic pseudocyst formation can prolong the hospital stay, delay chemotherapy, and necessitate long-term parenteral nutrition. We report 5 children with acute lymphoblastic leukemia who developed acute pancreatitis complicated by pancreatic pseudocysts. They required modifications to their chemotherapy regimen and prolonged parenteral nutrition but no surgical intervention. All 5 patients survive in first remission and their pseudocysts resolved after 3 to 37 months or continued to decrease in size at last follow-up. These cases illustrate that nonsurgical management of pancreatic pseudocyst is safe, though pseudocyst resolution may require many months. In addition, these patients demonstrate that oral feeding can be initiated after the acute episode of pancreatitis resolves even if a pseudocyst is present.

Original languageEnglish (US)
Pages (from-to)957-959
Number of pages3
JournalJournal of pediatric hematology/oncology
Volume31
Issue number12
DOIs
StatePublished - Dec 1 2009

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Pancreatic Pseudocyst
Precursor Cell Lymphoblastic Leukemia-Lymphoma
Pancreatitis
Parenteral Nutrition
Asparaginase
Drug Therapy
Length of Stay
Conservative Treatment

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Hematology
  • Oncology

Cite this

Conservative management of pancreatic pseudocysts in children with acute lymphoblastic leukemia. / Spraker, Holly L.; Spyridis, Georgios P.; Pui, Ching Hon; Howard, Scott.

In: Journal of pediatric hematology/oncology, Vol. 31, No. 12, 01.12.2009, p. 957-959.

Research output: Contribution to journalArticle

Spraker, Holly L. ; Spyridis, Georgios P. ; Pui, Ching Hon ; Howard, Scott. / Conservative management of pancreatic pseudocysts in children with acute lymphoblastic leukemia. In: Journal of pediatric hematology/oncology. 2009 ; Vol. 31, No. 12. pp. 957-959.
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