Constitutively active TRPC3 channels regulate basal ganglia output neurons

Fuwen Zhou, Shannon G. Matta, Fuming Zhou

Research output: Contribution to journalArticle

60 Citations (Scopus)

Abstract

A hallmark of the GABA projection neurons of the substantia nigra pars reticulata (SNr), a key basal ganglia output nucleus, is its depolarized membrane potential and rapid spontaneous spikes that encode the basal ganglia output. Parkinsonian movement disorders are often associated with abnormalities in SNr GABA neuron firing intensity and/or pattern. A fundamental question remains regarding the molecular identity of the ion channels that drive these neurons to a depolarized membrane potential. We show here that SNr GABA projection neurons selectively express type 3 canonical transient receptor potential (TRPC3) channels. These channels are tonically active and mediate an inward, Na+-dependent current, leading to a substantial depolarization in these neurons. Inhibition of TRPC3 channels induces hyperpolarization, decreases firing frequency, and increases firing irregularity. These data demonstrate that TRPC3 channels play important roles in ensuring the appropriate firing intensity and pattern in SNr GABA projection neurons that are crucial to movement control.

Original languageEnglish (US)
Pages (from-to)473-482
Number of pages10
JournalJournal of Neuroscience
Volume28
Issue number2
DOIs
StatePublished - Jan 9 2008

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GABAergic Neurons
Basal Ganglia
Neurons
Membrane Potentials
Transient Receptor Potential Channels
Movement Disorders
Parkinsonian Disorders
Ion Channels
Pars Reticulata
TRPC3 cation channel

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Constitutively active TRPC3 channels regulate basal ganglia output neurons. / Zhou, Fuwen; Matta, Shannon G.; Zhou, Fuming.

In: Journal of Neuroscience, Vol. 28, No. 2, 09.01.2008, p. 473-482.

Research output: Contribution to journalArticle

Zhou, Fuwen ; Matta, Shannon G. ; Zhou, Fuming. / Constitutively active TRPC3 channels regulate basal ganglia output neurons. In: Journal of Neuroscience. 2008 ; Vol. 28, No. 2. pp. 473-482.
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