Continuous flow microfluidic chemistry

Synthesis of [18F]-3-fluoro-2-(4-((2-nitro-1h-imidazol-1-yl)methyl)-1h-1,2,3-Triazol-1-yl)propan-1-ol, [18F]F-HX4, a potent hypoxia agent

Research output: Contribution to journalArticle

Abstract

The microfluidic synthesis of the promising hypoxia imaging agent [18F]-3-fluoro-2-(4-((2-nitro-1H-imidazol-1-yl)methyl)-1H-1,2,3-Triazol-1-yl)propan- 1-ol, [18F]F-HX4, was successfully accomplished using a commercial microfluidic system. A decay corrected radiochemical yield of 48±4% (n=4) and radiochemical purity of ≥ 98% was obtained. The total reaction time including the HPLC purification was 40 min.

Original languageEnglish (US)
Pages (from-to)745-754
Number of pages10
JournalHeterocycles
Volume93
Issue number2
DOIs
StatePublished - 2016

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Microfluidics
Purification
High Pressure Liquid Chromatography
Imaging techniques
3-fluoro-2-(4-((2-nitro-1H-imidazol-1-yl)methyl)-1H-1,2,3-triazol-1-yl)propan-1-ol
Hypoxia

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Pharmacology
  • Organic Chemistry

Cite this

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title = "Continuous flow microfluidic chemistry: Synthesis of [18F]-3-fluoro-2-(4-((2-nitro-1h-imidazol-1-yl)methyl)-1h-1,2,3-Triazol-1-yl)propan-1-ol, [18F]F-HX4, a potent hypoxia agent",
abstract = "The microfluidic synthesis of the promising hypoxia imaging agent [18F]-3-fluoro-2-(4-((2-nitro-1H-imidazol-1-yl)methyl)-1H-1,2,3-Triazol-1-yl)propan- 1-ol, [18F]F-HX4, was successfully accomplished using a commercial microfluidic system. A decay corrected radiochemical yield of 48±4{\%} (n=4) and radiochemical purity of ≥ 98{\%} was obtained. The total reaction time including the HPLC purification was 40 min.",
author = "Murthy Akula and David Blevins and George Kabalka",
year = "2016",
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language = "English (US)",
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publisher = "Japan Institute of Heterocyclic Chemistry",
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