Contribution of cytochrome P450 1B1 to hypertension and associated pathophysiology

A novel target for antihypertensive agents

Kafait Malik, Brett L. Jennings, Fariborz A. Yaghini, Seyhan Sahan-Firat, Chi Young Song, Anne M. Estes, Xiao R. Fang

Research output: Contribution to journalReview article

13 Citations (Scopus)

Abstract

The aim of this review is to discuss the contribution of cytochrome P450 (CYP) 1B1 in vascular smooth muscle cell growth, hypertension, and associated pathophysiology. CYP1B1 is expressed in cardiovascular and renal tissues, and mediates angiotensin II (Ang II)-induced activation of NADPH oxidase and generation of reactive oxygen species (ROS), and vascular smooth muscle cell migration, proliferation, and hypertrophy. Moreover, CYP1B1 contributes to the development and/or maintenance of hypertension produced by Ang II-, deoxycorticosterone (DOCA)-salt-, and Nω-nitro-L-arginine methyl ester-induced hypertension and in spontaneously hypertensive rats. The pathophysiological changes, including cardiovascular hypertrophy, increased vascular reactivity, endothelial and renal dysfunction, injury and inflammation associated with Ang II- and/or DOCA-salt induced hypertension in rats, and Ang II-induced hypertension in mice are minimized by inhibition of CYP1B1 activity with 2,4,3′,5′-tetramethoxystilbene or by Cyp1b1 gene disruption in mice. These pathophysiological changes appear to be mediated by increased production of ROS via CYP1B1-dependent NADPH oxidase activity and extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase, and c-Src.

Original languageEnglish (US)
Pages (from-to)69-74
Number of pages6
JournalProstaglandins and Other Lipid Mediators
Volume98
Issue number3-4
DOIs
StatePublished - Aug 1 2012

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Angiotensin II
Cytochrome P-450 Enzyme System
Antihypertensive Agents
Desoxycorticosterone Acetate
Hypertension
NADPH Oxidase
Muscle
Rats
Reactive Oxygen Species
Vascular Smooth Muscle
Salts
Hypertrophy
Smooth Muscle Myocytes
Desoxycorticosterone
Mitogen-Activated Protein Kinase 3
Cell growth
p38 Mitogen-Activated Protein Kinases
Kidney
Mitogen-Activated Protein Kinase 1
Inbred SHR Rats

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physiology
  • Pharmacology
  • Cell Biology

Cite this

Contribution of cytochrome P450 1B1 to hypertension and associated pathophysiology : A novel target for antihypertensive agents. / Malik, Kafait; Jennings, Brett L.; Yaghini, Fariborz A.; Sahan-Firat, Seyhan; Song, Chi Young; Estes, Anne M.; Fang, Xiao R.

In: Prostaglandins and Other Lipid Mediators, Vol. 98, No. 3-4, 01.08.2012, p. 69-74.

Research output: Contribution to journalReview article

Malik, Kafait ; Jennings, Brett L. ; Yaghini, Fariborz A. ; Sahan-Firat, Seyhan ; Song, Chi Young ; Estes, Anne M. ; Fang, Xiao R. / Contribution of cytochrome P450 1B1 to hypertension and associated pathophysiology : A novel target for antihypertensive agents. In: Prostaglandins and Other Lipid Mediators. 2012 ; Vol. 98, No. 3-4. pp. 69-74.
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