Contribution of vasopressin in dexamethasone-induced hypertension in rats

Fujio Lijima, Kafait Malik

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Our previous finding that dexamethasone-induced hypertension in rats is associated with enhanced reactivity of mesenteric arteries to arginine vasopressin but not to angiotensin II (Ang II) or norepinephrine has led us to postulate that vasopressin contributes to the development or maintenance of glucocorticoid-induced hypertension. To test this view, we investigated the effects of vasopressin, Ang II, norepinephrine, and the vasopressin V1 receptor antagonist d(CH2)5Tyr(Me)AVP on mean arterial blood pressure and heart rate with and without ganglionic blockade with hexamethonium and angiotensin I (Ang I) converting enzyme inhibition with MK 421 in pentobarbitalanesthetized rats made hypertensive by treatment with dexamethasone (1.8 mg/kg/wk for 14 days). Administration of vasopressin, Ang II, or norepinephrine (0.003-3 μg I.v.) produced a dose-related increase in arterial blood pressure. The pressor response to vasopressin, but not to Ang II or norepinephrine, was greater in dexamethasone-treated than in vehicle-treated animals, and this difference became more pronounced in rats that received hexamethonium and MK 421. Administration of the vasopressin V1 receptor antagonist d(CH2)5Tyr(Me)AVP significantly reduced arterial pressure in dexamethasone-treated but not in vehicle-treated nnimnls. Hexamethonium and MK 421 reduced arterial blood pressure in dexamethasone-treated as well as in vehicle-treated rats; however, arterial blood pressure remained higher in the former. Administration of the vasopressin V1 receptor antagonist produced a greater reduction in arterial blood pressure in dexamethasone-treated than in vehicle-treated rats. These data suggest that vasopressin contributes to glucocorticoid-induced hypertension, which is probably due to enhanced vascular reactivity to the peptide.

Original languageEnglish (US)
Pages (from-to)I-42-I-46
JournalHypertension
Volume11
Issue number2
StatePublished - Jan 1 1988

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Vasopressins
Dexamethasone
Arterial Pressure
Hypertension
Angiotensin II
Vasopressin Receptors
Hexamethonium
Enalapril
Norepinephrine
Glucocorticoids
Mesenteric Arteries
Arginine Vasopressin
Peptidyl-Dipeptidase A
Blood Vessels
Heart Rate
Maintenance
Peptides
Antidiuretic Hormone Receptor Antagonists

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Contribution of vasopressin in dexamethasone-induced hypertension in rats. / Lijima, Fujio; Malik, Kafait.

In: Hypertension, Vol. 11, No. 2, 01.01.1988, p. I-42-I-46.

Research output: Contribution to journalArticle

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