Control of ras-mediated signaling in aspergillus fumigatus

Tiffany S. Norton, Jarrod Fortwendel

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Pathogenic fungi employ numerous mechanisms to flourish in the stressful environment encountered within their mammalian hosts. Central to this arsenal for filamentous fungi is invasive growth within the host microenvironment, mediated by establishment and maintenance of polarized hyphal morphogenesis. In Aspergillus fumigatus, the RasA signal transduction pathway has emerged as a significant regulator of hyphal morphogenesis and virulence, among other processes. The factors contributing to the regulation of RasA itself are not as thoroughly understood, although proper temporal activation of RasA and spatial localization of RasA to the plasma membrane are known to play major roles. Interference with RasA palmitoylation or prenylation results in mislocalization of RasA and is associated with severe growth deficits. In addition, dysregulation of RasA activation results in severe morphologic aberrancies and growth deficits. This review highlights the relationship between RasA signaling, hyphal morphogenesis, and virulence in A. fumigatus and focuses on potential determinants of spatial and temporal RasA regulation.

Original languageEnglish (US)
Pages (from-to)325-330
Number of pages6
JournalMycopathologia
Volume178
Issue number5-6
DOIs
StatePublished - Nov 20 2014
Externally publishedYes

Fingerprint

Aspergillus fumigatus
Morphogenesis
morphogenesis
Virulence
Fungi
virulence
Growth
Lipoylation
Prenylation
fungi
signal transduction
Signal Transduction
plasma membrane
Maintenance
Cell Membrane

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Applied Microbiology and Biotechnology
  • veterinary (miscalleneous)
  • Agronomy and Crop Science
  • Plant Science

Cite this

Control of ras-mediated signaling in aspergillus fumigatus. / Norton, Tiffany S.; Fortwendel, Jarrod.

In: Mycopathologia, Vol. 178, No. 5-6, 20.11.2014, p. 325-330.

Research output: Contribution to journalArticle

Norton, Tiffany S. ; Fortwendel, Jarrod. / Control of ras-mediated signaling in aspergillus fumigatus. In: Mycopathologia. 2014 ; Vol. 178, No. 5-6. pp. 325-330.
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