Conversion of m serotype 24 of Streptococcus pyogenes to M serotypes 5 and 18

Effect on resistance to phagocytosis and adhesion to host cells

Harry Courtney, Shaoyou Liu, James Dale, David L. Hasty

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

In this study, we utilized recombinant strains expressing the M5 and M18 proteins and M- mutants of group A streptococci to compare the abilities of these M proteins to confer resistance to phagocytosis and to mediate adhesion to host cells. The data indicate that the M5 and M18 proteins can confer resistance to phagocytosis, that fibrinogen is required for this resistance, and that these M proteins can mediate adhesion to HEp-2 cells.

Original languageEnglish (US)
Pages (from-to)2472-2474
Number of pages3
JournalInfection and Immunity
Volume65
Issue number6
StatePublished - Jun 18 1997

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Streptococcus pyogenes
Phagocytosis
Proteins
Mutant Proteins
Streptococcus
Fibrinogen
Serogroup

All Science Journal Classification (ASJC) codes

  • Parasitology
  • Microbiology
  • Immunology
  • Infectious Diseases

Cite this

Conversion of m serotype 24 of Streptococcus pyogenes to M serotypes 5 and 18 : Effect on resistance to phagocytosis and adhesion to host cells. / Courtney, Harry; Liu, Shaoyou; Dale, James; Hasty, David L.

In: Infection and Immunity, Vol. 65, No. 6, 18.06.1997, p. 2472-2474.

Research output: Contribution to journalArticle

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