Copper and Hypoxia-Inducible Transcription Factor Regulation of Gene Expression

Wenjing Zhang, Ying Xiao, Wen Yin, Tao Wang, Yujian Kang

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The master regulator of oxygen homeostasis, hypoxia-inducible transcription factor (HIF), is a heterodimer composed of HIF-1α or HIF-2α and HIF1α, and it controls a diversity of cellular events. Under hypoxic condition, HIF-1 specifically upregulates the expression of a group of genes involved in angiogenesis. This specificity of HIF-1 regulation of gene expression requires copper, which promotes HIF-1 transcriptional complex formation and its interaction with hypoxia-response element. A long-term ischemic stress causes copper efflux from tissues, leading to suppressed expression of angiogenesis genes, not other genes. The copper-dependent and copper-independent HIF-1 regulation of angiogenesis provides a fundamental understanding of ischemic disease and of experimental and clinical approaches for intervention.

Original languageEnglish (US)
Title of host publicationMolecular, Genetic, and Nutritional Aspects of Major and Trace Minerals
PublisherElsevier Inc.
Pages101-113
Number of pages13
ISBN (Electronic)9780128023761
ISBN (Print)9780128021682
DOIs
StatePublished - Jan 1 2017

Fingerprint

Gene Expression Regulation
Hypoxia-Inducible Factor 1
Copper
Transcription Factors
Response Elements
Hypoxia
Genes
Homeostasis
Up-Regulation
Oxygen
Gene Expression

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Zhang, W., Xiao, Y., Yin, W., Wang, T., & Kang, Y. (2017). Copper and Hypoxia-Inducible Transcription Factor Regulation of Gene Expression. In Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals (pp. 101-113). Elsevier Inc.. https://doi.org/10.1016/B978-0-12-802168-2.00009-9

Copper and Hypoxia-Inducible Transcription Factor Regulation of Gene Expression. / Zhang, Wenjing; Xiao, Ying; Yin, Wen; Wang, Tao; Kang, Yujian.

Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Elsevier Inc., 2017. p. 101-113.

Research output: Chapter in Book/Report/Conference proceedingChapter

Zhang, W, Xiao, Y, Yin, W, Wang, T & Kang, Y 2017, Copper and Hypoxia-Inducible Transcription Factor Regulation of Gene Expression. in Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Elsevier Inc., pp. 101-113. https://doi.org/10.1016/B978-0-12-802168-2.00009-9
Zhang W, Xiao Y, Yin W, Wang T, Kang Y. Copper and Hypoxia-Inducible Transcription Factor Regulation of Gene Expression. In Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Elsevier Inc. 2017. p. 101-113 https://doi.org/10.1016/B978-0-12-802168-2.00009-9
Zhang, Wenjing ; Xiao, Ying ; Yin, Wen ; Wang, Tao ; Kang, Yujian. / Copper and Hypoxia-Inducible Transcription Factor Regulation of Gene Expression. Molecular, Genetic, and Nutritional Aspects of Major and Trace Minerals. Elsevier Inc., 2017. pp. 101-113
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