Core-shell-type lipid-polymer hybrid nanoparticles as a drug delivery platform

Bivash Mandal, Himanshu Bhattacharjee, Nivesh Mittal, Hongkee Sah, Pavan Balabathula, Laura Thoma, George C. Wood

Research output: Contribution to journalReview article

175 Citations (Scopus)

Abstract

The focus of nanoparticle design over the years has evolved toward more complex nanoscopic core-shell architecture using a single delivery system to combine multiple functionalities within nanoparticles. Core-shell-type lipid-polymer hybrid nanoparticles (CSLPHNs), which combine the mechanical advantages of biodegradable polymeric nanoparticles and biomimetic advantages of liposomes, have emerged as a robust and promising delivery platform. In CSLPHNs, a biodegradable polymeric core is surrounded by a shell composed of layer(s) of phospholipids. The hybrid architecture can provide advantages such as controllable particle size, surface functionality, high drug loading, entrapment of multiple therapeutic agents, tunable drug release profile, and good serum stability. This review focuses on current research trends on CSLPHNs including classification, advantages, methods of preparation, physicochemical characteristics, surface modifications, and immunocompatibility. Additionally, the review deals with applications for cancer chemotherapy, vaccines, and gene therapeutics. From the Clinical Editor: This comprehensive review covers the current applications of core-shell-type lipid-polymer hybrid nanoparticles, which combine the mechanical advantages of biodegradable polymeric nanoparticles and biomimetic advantages of liposomes to enable an efficient drug delivery system.

Original languageEnglish (US)
Pages (from-to)474-491
Number of pages18
JournalNanomedicine: Nanotechnology, Biology, and Medicine
Volume9
Issue number4
DOIs
StatePublished - May 1 2013

Fingerprint

Drug delivery
Nanoparticles
Lipids
Polymers
Pharmaceutical Preparations
Biomimetics
Liposomes
Cancer Vaccines
Histocompatibility
Chemotherapy
Vaccines
Neoplasm Genes
Phospholipids
Drug Delivery Systems
Particle Size
Surface treatment
Genes
Particle size
Drug Therapy
Therapeutics

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Medicine (miscellaneous)
  • Molecular Medicine
  • Biomedical Engineering
  • Materials Science(all)
  • Pharmaceutical Science

Cite this

Mandal, B., Bhattacharjee, H., Mittal, N., Sah, H., Balabathula, P., Thoma, L., & Wood, G. C. (2013). Core-shell-type lipid-polymer hybrid nanoparticles as a drug delivery platform. Nanomedicine: Nanotechnology, Biology, and Medicine, 9(4), 474-491. https://doi.org/10.1016/j.nano.2012.11.010

Core-shell-type lipid-polymer hybrid nanoparticles as a drug delivery platform. / Mandal, Bivash; Bhattacharjee, Himanshu; Mittal, Nivesh; Sah, Hongkee; Balabathula, Pavan; Thoma, Laura; Wood, George C.

In: Nanomedicine: Nanotechnology, Biology, and Medicine, Vol. 9, No. 4, 01.05.2013, p. 474-491.

Research output: Contribution to journalReview article

Mandal, B, Bhattacharjee, H, Mittal, N, Sah, H, Balabathula, P, Thoma, L & Wood, GC 2013, 'Core-shell-type lipid-polymer hybrid nanoparticles as a drug delivery platform', Nanomedicine: Nanotechnology, Biology, and Medicine, vol. 9, no. 4, pp. 474-491. https://doi.org/10.1016/j.nano.2012.11.010
Mandal, Bivash ; Bhattacharjee, Himanshu ; Mittal, Nivesh ; Sah, Hongkee ; Balabathula, Pavan ; Thoma, Laura ; Wood, George C. / Core-shell-type lipid-polymer hybrid nanoparticles as a drug delivery platform. In: Nanomedicine: Nanotechnology, Biology, and Medicine. 2013 ; Vol. 9, No. 4. pp. 474-491.
@article{d0f484928eb442689299feadea29304c,
title = "Core-shell-type lipid-polymer hybrid nanoparticles as a drug delivery platform",
abstract = "The focus of nanoparticle design over the years has evolved toward more complex nanoscopic core-shell architecture using a single delivery system to combine multiple functionalities within nanoparticles. Core-shell-type lipid-polymer hybrid nanoparticles (CSLPHNs), which combine the mechanical advantages of biodegradable polymeric nanoparticles and biomimetic advantages of liposomes, have emerged as a robust and promising delivery platform. In CSLPHNs, a biodegradable polymeric core is surrounded by a shell composed of layer(s) of phospholipids. The hybrid architecture can provide advantages such as controllable particle size, surface functionality, high drug loading, entrapment of multiple therapeutic agents, tunable drug release profile, and good serum stability. This review focuses on current research trends on CSLPHNs including classification, advantages, methods of preparation, physicochemical characteristics, surface modifications, and immunocompatibility. Additionally, the review deals with applications for cancer chemotherapy, vaccines, and gene therapeutics. From the Clinical Editor: This comprehensive review covers the current applications of core-shell-type lipid-polymer hybrid nanoparticles, which combine the mechanical advantages of biodegradable polymeric nanoparticles and biomimetic advantages of liposomes to enable an efficient drug delivery system.",
author = "Bivash Mandal and Himanshu Bhattacharjee and Nivesh Mittal and Hongkee Sah and Pavan Balabathula and Laura Thoma and Wood, {George C.}",
year = "2013",
month = "5",
day = "1",
doi = "10.1016/j.nano.2012.11.010",
language = "English (US)",
volume = "9",
pages = "474--491",
journal = "Nanomedicine: Nanotechnology, Biology, and Medicine",
issn = "1549-9634",
publisher = "Elsevier Inc.",
number = "4",

}

TY - JOUR

T1 - Core-shell-type lipid-polymer hybrid nanoparticles as a drug delivery platform

AU - Mandal, Bivash

AU - Bhattacharjee, Himanshu

AU - Mittal, Nivesh

AU - Sah, Hongkee

AU - Balabathula, Pavan

AU - Thoma, Laura

AU - Wood, George C.

PY - 2013/5/1

Y1 - 2013/5/1

N2 - The focus of nanoparticle design over the years has evolved toward more complex nanoscopic core-shell architecture using a single delivery system to combine multiple functionalities within nanoparticles. Core-shell-type lipid-polymer hybrid nanoparticles (CSLPHNs), which combine the mechanical advantages of biodegradable polymeric nanoparticles and biomimetic advantages of liposomes, have emerged as a robust and promising delivery platform. In CSLPHNs, a biodegradable polymeric core is surrounded by a shell composed of layer(s) of phospholipids. The hybrid architecture can provide advantages such as controllable particle size, surface functionality, high drug loading, entrapment of multiple therapeutic agents, tunable drug release profile, and good serum stability. This review focuses on current research trends on CSLPHNs including classification, advantages, methods of preparation, physicochemical characteristics, surface modifications, and immunocompatibility. Additionally, the review deals with applications for cancer chemotherapy, vaccines, and gene therapeutics. From the Clinical Editor: This comprehensive review covers the current applications of core-shell-type lipid-polymer hybrid nanoparticles, which combine the mechanical advantages of biodegradable polymeric nanoparticles and biomimetic advantages of liposomes to enable an efficient drug delivery system.

AB - The focus of nanoparticle design over the years has evolved toward more complex nanoscopic core-shell architecture using a single delivery system to combine multiple functionalities within nanoparticles. Core-shell-type lipid-polymer hybrid nanoparticles (CSLPHNs), which combine the mechanical advantages of biodegradable polymeric nanoparticles and biomimetic advantages of liposomes, have emerged as a robust and promising delivery platform. In CSLPHNs, a biodegradable polymeric core is surrounded by a shell composed of layer(s) of phospholipids. The hybrid architecture can provide advantages such as controllable particle size, surface functionality, high drug loading, entrapment of multiple therapeutic agents, tunable drug release profile, and good serum stability. This review focuses on current research trends on CSLPHNs including classification, advantages, methods of preparation, physicochemical characteristics, surface modifications, and immunocompatibility. Additionally, the review deals with applications for cancer chemotherapy, vaccines, and gene therapeutics. From the Clinical Editor: This comprehensive review covers the current applications of core-shell-type lipid-polymer hybrid nanoparticles, which combine the mechanical advantages of biodegradable polymeric nanoparticles and biomimetic advantages of liposomes to enable an efficient drug delivery system.

UR - http://www.scopus.com/inward/record.url?scp=84876710834&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876710834&partnerID=8YFLogxK

U2 - 10.1016/j.nano.2012.11.010

DO - 10.1016/j.nano.2012.11.010

M3 - Review article

VL - 9

SP - 474

EP - 491

JO - Nanomedicine: Nanotechnology, Biology, and Medicine

JF - Nanomedicine: Nanotechnology, Biology, and Medicine

SN - 1549-9634

IS - 4

ER -